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Invitrogen™ HMGCR Monoclonal Antibody (CL0259)
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Catalog No. PIMA531335
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100 μL
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Catalog No. Quantity
PIMA531335 100 μL
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Catalog No. PIMA531335 Supplier Invitrogen™ Supplier No. MA531335
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Description

Mouse Monoclonal Antibody

Immunogen sequence: HIPAYKLETL METHERGVSI RRQLLSKKLS EPSSLQYLPY RDYNYSLVMG ACCENVIGYM PIPVGVAGPL CLDEKEFQVP MATTEGCLVA Highest antigen sequence indentity to the following orthologs: Mouse - 96%, Rat - 96%.

3-Hydroxy-3-Methylglutaryl-CoA Reductase (HMGCR) is a key enzyme in the mevalonate pathway, which is critical for the biosynthesis of cholesterol and other isoprenoids. HMGCR catalyzes the conversion of HMG-CoA to mevalonate, a rate-limiting step in the production of cholesterol. Due to its central role in cholesterol synthesis, HMGCR is a primary target for statin drugs, which are used to lower cholesterol levels and reduce the risk of cardiovascular disease.
TRUSTED_SUSTAINABILITY

Specifications

Antigen HMGCR
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Monoclonal
Clone CL0259
Concentration 0.6 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene HMGCR
Gene Accession No. P04035
Gene Alias 3H3M; 3-hydroxy-3-methylglutaryl CoA reductase (NADPH); 3-hydroxy-3-methylglutaryl-CoA reductase; 3-hydroxy-3-methylglutaryl-Coenzyme A reductase; HMDH; HMG CoA reductase; HMG CoAR; HMG-CoA reductase; HMG-CoAR; HMGCR; hydroxymethylglutaryl-CoA reductase; LDLCQ3; MGC103269; Red
Gene Symbols HMGCR
Host Species Mouse
Immunogen Recombinant protein corresponding to Human HMGCR.
Purification Method Protein A
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 3156
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG2a
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