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Invitrogen™ HMGCR Recombinant Rabbit Monoclonal Antibody (JF0981)
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Catalog No. PIMA532521
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Quantity:
100 μL
Catalog No. Quantity
PIMA532521 100 μL
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Catalog No. PIMA532521

Supplier: Invitrogen™ MA532521

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Description

Rabbit Recombinant Monoclonal Antibody

Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.

3-Hydroxy-3-Methylglutaryl-CoA Reductase (HMGCR) is a key enzyme in the mevalonate pathway, which is critical for the biosynthesis of cholesterol and other isoprenoids. HMGCR catalyzes the conversion of HMG-CoA to mevalonate, a rate-limiting step in the production of cholesterol. Due to its central role in cholesterol synthesis, HMGCR is a primary target for statin drugs, which are used to lower cholesterol levels and reduce the risk of cardiovascular disease.
TRUSTED_SUSTAINABILITY

Specifications

Antigen HMGCR
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Recombinant Monoclonal
Clone JF0981
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation TBS with 0.05% BSA, 40% Glycerol and 0.05% sodium azide; pH 7.4
Gene HMGCR
Gene Accession No. P04035, P51639, Q01237
Gene Alias 3H3M; 3-hydroxy-3-methylglutaryl CoA reductase (NADPH); 3-hydroxy-3-methylglutaryl-CoA reductase; 3-hydroxy-3-methylglutaryl-Coenzyme A reductase; HMDH; HMG CoA reductase; HMG CoAR; HMG-CoA reductase; HMG-CoAR; HMGCR; hydroxymethylglutaryl-CoA reductase; LDLCQ3; MGC103269; Red
Gene Symbols HMGCR
Host Species Rabbit
Immunogen Synthetic peptide within Human HMGCR aa 438-489.
Purification Method Protein A
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 15357, 25675, 3156
Target Species Human, Mouse, Rat
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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