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Invitrogen™ HNF1A Monoclonal Antibody (GT4110)
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Catalog No. PIMA517267
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100 μL
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PIMA517267 100 μL
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Catalog No. PIMA517267 Supplier Invitrogen™ Supplier No. MA517267
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Description

Mouse Monoclonal Antibody

Recommended positive controls: HeLa, mouse liver. Predicted reactivity: Mouse (99%), Rat (99%), Xenopus laevis (83%), Pig (99%), Chicken (95%), Bovine (98%). Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

This gene is expressed ubiquitously with higher levels in fetal than in adult tissues. It encodes a protein sharing 93% sequence identity with the mouse protein. Wolf-Hirschhorn syndrome (WHS) is a malformation syndrome associated with a hemizygous deletion of the distal short arm of chromosome 4. This gene is mapped to the 165 kb WHS critical region, and may play a role in the phenotype of the WHS or Pitt-Rogers-Danks syndrome. The encoded protein is found to be capable of reacting with HLA-A2-restricted and tumor-specific cytotoxic T lymphocytes, suggesting a target for use in specific immunotherapy for a large number of cancer patients. This protein has also been shown to be a member of the NELF (negative elongation factor) protein complex that participates in the regulation of RNA polymerase II transcription elongation.
TRUSTED_SUSTAINABILITY

Specifications

Antigen HNF1A
Applications Immunohistochemistry (Paraffin), Western Blot, Western Blot
Classification Monoclonal
Clone GT4110
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with no preservative
Gene Hnf1a
Gene Accession No. P20823, P22361
Gene Alias AI323641; albumin proximal factor; hepatic nuclear factor 1; hepatic nuclear factor-1-alpha; hepatocyte nuclear factor 1; hepatocyte nuclear factor 1-alpha; Hepatocyte nuclear factor 1-alpha-A; HNF1; Hnf-1; hnf-1 alpha; HNF1 homeobox A; HNF1 homeobox A L homeolog; HNF1 homeobox A S homeolog; HNF1[a]; hnf1a; Hnf-1a; hnf1-a; hnf1a.L; hnf1a.S; HNF-1A-A; hnf1a-a; hnf1a-b; Hnf1alpha; HNF-1-alpha; HNF1-alpha; HNF-1-alpha-A; I79_010330; IDDM20; interferon production regulator factor; LFB1; LF-B1; LF-B1 hepatic nuclear factor (HNF1): albumin proximal factor also TCF1; LF-B1, hepatic nuclear factor (HNF1): albumin proximal factor, also TCF1; lfb1a; LFB1a1; Liver-specific transcription factor LF-B1; MODY3; TCF1; Tcf-1; TCF-1-A; tcf1-a; transcription factor 1; Transcription factor 1 hepatic; Transcription factor 1, hepatic; transcription factor 1, transcription factor LFB1 /HNF1; transcription factor 1-A; XELAEV_18010473mg; XLFB1; XLFB1a; XLFB1b
Gene Symbols Hnf1a
Host Species Mouse
Immunogen Recombinant protein encompassing a sequence within the center region of human HNF1 alpha. The exact sequence is proprietary.
Purification Method Protein G
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 21405, 6927
Target Species Human, Mouse
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG2a
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