Invitrogen™ HNF1A Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA5116983

Catalog No. PIPA5116983

Description

Positive Samples: 293T, LO2 Immunogen sequence: LGEPGPYLLA GEGPLDKGES CGGGRGELAE LPNGLGETRG SEDETDDDGE DFTPPILKEL ENLSPEEAAH QKAVVETLLQ EDPWRVAKMV KSYLQQHNIP Q.

This gene is expressed ubiquitously with higher levels in fetal than in adult tissues. It encodes a protein sharing 93% sequence identity with the mouse protein. Wolf-Hirschhorn syndrome (WHS) is a malformation syndrome associated with a hemizygous deletion of the distal short arm of chromosome 4. This gene is mapped to the 165 kb WHS critical region, and may play a role in the phenotype of the WHS or Pitt-Rogers-Danks syndrome. The encoded protein is found to be capable of reacting with HLA-A2-restricted and tumor-specific cytotoxic T lymphocytes, suggesting a target for use in specific immunotherapy for a large number of cancer patients. This protein has also been shown to be a member of the NELF (negative elongation factor) protein complex that participates in the regulation of RNA polymerase II transcription elongation.

Specifications

• Antigen: HNF1A
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: Hnf1a
• Gene Alias: AI323641; albumin proximal factor; hepatic nuclear factor 1; hepatic nuclear factor-1-alpha; hepatocyte nuclear factor 1; hepatocyte nuclear factor 1-alpha; Hepatocyte nuclear factor 1-alpha-A; HNF1; Hnf-1; hnf-1 alpha; HNF1 homeobox A; HNF1 homeobox A L homeolog; HNF1 homeobox A S homeolog; HNF1[a]; hnf1a; Hnf-1a; hnf1-a; hnf1a.L; hnf1a.S; HNF-1A-A; hnf1a-a; hnf1a-b; Hnf1alpha; HNF-1-alpha; HNF1-alpha; HNF-1-alpha-A; I79_010330; IDDM20; interferon production regulator factor; LFB1; LF-B1; LF-B1 hepatic nuclear factor (HNF1): albumin proximal factor also TCF1; LF-B1, hepatic nuclear factor (HNF1): albumin proximal factor, also TCF1; lfb1a; LFB1a1; Liver-specific transcription factor LF-B1; MODY3; TCF1; Tcf-1; TCF-1-A; tcf1-a; transcription factor 1; Transcription factor 1 hepatic; Transcription factor 1, hepatic; transcription factor 1, transcription factor LFB1 /HNF1; transcription factor 1-A; XELAEV_18010473mg; XLFB1; XLFB1a; XLFB1b
• Host Species: Rabbit
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 21405, 24817, 6927
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: ELISA, Western Blot
• Concentration: 0.62 mg/mL
• Formulation: PBS with 50% glycerol and 0.05% ProClin 300; pH 7.3
• Gene Accession No.: P15257, P20823, P22361
• Gene Symbols: Hnf1a
• Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 30-130 of human HNF1a (NP_0005366).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG