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Invitrogen™ HNF4A Monoclonal Antibody (6C8E9)
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Catalog No. PIMA549152
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PIMA549152 100 μg
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Catalog No. PIMA549152 Supplier Invitrogen™ Supplier No. MA549152
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Description

Mouse Monoclonal Antibody

Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL. Human HNF-4-alpha shares 95% and 96% amino acid (aa) sequence identity with mouse and rat HNF-4-alpha, respectively. Positive Control - WB: human HepG2 whole cell, rat liver tissue. IHC: rat colon tissue, rat liver tissue. Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Hepatocyte nuclear factor 4 alpha (HNF4 alpha) is an orphan nuclear receptor. HNF4a is expressed in the liver, kidney, intestine, and pancreas. Mutation of HNF4a in humans has been associated with maturity-onset diabetes of the young type 1 (MODY1). HNF4 binds to DNA as an exclusive homodimer. The HNF4a gene is alternatively spliced and may generate up to nine different isoforms, HNF4a1 through HNF4a9.
TRUSTED_SUSTAINABILITY

Specifications

Antigen HNF4A
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Monoclonal
Clone 6C8E9
Concentration 500 μg/mL
Conjugate Unconjugated
Formulation PBS with 4mg trehalose and no preservative
Gene HNF4A
Gene Accession No. P22449, P41235
Gene Alias alpha transcription factor 4; FLJ39654; FRTS4; hepatic nuclear factor 4 alpha; hepatic nuclear factor 4, alpha; hepatocyte nuclear factor 4 alpha; hepatocyte nuclear factor 4, alpha; hepatocyte nuclear factor 4-alpha; HNF4; Hnf-4; HNF4 alpha; Hnf4a; HNF4a7; HNF4a8; HNF4a9; Hnf4alpha; HNF-4-alpha; HNF4-alpha; HNF4alpha10; HNF4alpha10/11/12; HNF4alpha11; HNF4alpha12; MODY; MODY1; NR2A1; NR2A21; Nuclear receptor 2A1; nuclear receptor subfamily 2 group A member 1; TCF; TCF14; TCF-14; Transcription factor 14; transcription factor HNF-4
Gene Symbols HNF4A
Host Species Mouse
Immunogen E.coli-derived human HNF-4-alpha recombinant protein (Position: Q164-I474).
Purification Method Antigen affinity chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 25735, 3172
Target Species Human, Rat
Content And Storage -20°C
Product Type Antibody
Form Lyophilized
Isotype IgG2a
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