Invitrogen™ HNMT Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA557288

Catalog No. PIPA557288

Description

Immunogen sequence: TSDDLTQMLD NLGLKYECYD LLSTMDISDC FIDGNENGDL LWDFLTETCN FNATAPPDLR AELGKDLQEP EFSAKKEGKV LFNNTLSFIV IEA Highest antigen sequence identity to the following orthologs: Mouse - 83%, Rat - 83%.

In mammals, histamine is metabolized by two major pathways: N(tau)-methylation via histamine N-methyltransferase and oxidative deamination via diamine oxidase. HNMT is the first enzyme which is found in the cytosol and uses S-adenosyl-L-methionine as the methyl donor. In the mammalian brain, the neurotransmitter activity of histamine is controlled by N(tau)-methylation as diamine oxidase is not found in the central nervous system. A common genetic polymorphism affects the activity levels of this gene product in red blood cells.

Specifications

• Antigen: HNMT
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: Hnmt
• Gene Alias: 1500031F01Rik; AI788969; histamine N-methyltransferase; Hmt; Hnmt; HNMT-S1; HNMT-S2; MRT51
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 3176
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Concentration: 0.2 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: P50135
• Gene Symbols: Hnmt
• Immunogen: Recombinant protein corresponding to Human HNMT. Recombinant protein control fragment (Product #RP-102666).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov