hnRNP A1 Polyclonal Antibody, Invitrogen™

Rabbit Polyclonal Antibody

Supplier:  Thermo Scientific PA519431

Catalog No. PIPA519431

Description

Heat mediated antigen retrieval recommended prior to tissue staining. This antibody is predicted to react with mouse, rat and macaque monkey based on sequence homology. Store antibody at 4oC for 1-2 weeks. For long-term storage, store at -20oC.

HnRNP A1 belongs to the A/B subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre mRNAs in the nucleus and appear to influence pre mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. hnRNP A1 has two repeats of quasi RRM domains that bind to RNAs. It is one of the most abundant core proteins of hnRNP complexes and it is localized to the nucleoplasm. This protein, along with other hnRNP proteins, is exported from the nucleus, probably bound to mRNA, and is immediately re imported.

Specifications

• Antigen: hnRNP A1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: Hnrnpa1
• Gene Alias: ALS19; ALS20; Fli-2; Hdp; HDP-1; Helix-destabilizing protein; heterogeneous nuclear ribonucleoprotein A1; Heterogeneous nuclear ribonucleoprotein A1, N-terminally processed; heterogeneous nuclear ribonucleoprotein A1B protein; heterogeneous nuclear ribonucleoprotein B2 protein; heterogeneous nuclear ribonucleoprotein core protein A1; hnRNP A1; hnRNP A1-like 3; hnRNP core protein A1; hnRNP core protein A1-like 3; hnRNP I; Hnrnpa1; hnRNP-A1; HNRNPI; HNRNP-I; Hnrpa1; HNRPA1L3; HNRPA1MGC102835; HNRPI; I79_022927; IBMPFD3; MGC102835; MGC128297 protein; nuclear ribonucleoprotein particle A1 protein; pPTB; PTB; PTB-1; PTB2; PTB3; PTB4; PTB-T; putative heterogeneous nuclear ribonucleoprotein A1-like 3; Putative heterogeneous nuclear ribonucleoprotein A1-like protein 3; ROA1; RP11-78J21.1; single-strand DNA-binding protein UP1; single-strand RNA-binding protein; Single-strand-binding protein; Tis; Topoisomerase-inhibitor suppressed; unwinding protein 1; UP 1; UP1
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 3178
• Content And Storage: -20°C or -80°C if preferred
• Form: Liquid

• Applications: Immunocytochemistry, Immunohistochemistry (Paraffin), Immunoprecipitation, Immunoprecipitation, Western Blot
• Concentration: 0.9 mg/mL
• Formulation: PBS with 1% BSA and 0.02% sodium azide; pH 7.4
• Gene Accession No.: P09651
• Gene Symbols: Hnrnpa1
• Immunogen: Synthetic peptide derived from residues 300 to the C-terminus of Human hnRNP A1.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov