Invitrogen™ hnRNP L Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA597050

Catalog No. PIPA597050

Description

Immunogen sequence: TWDYTNPNLS GQGDPGSNPN KRQRQPPLLG DHPAEYGGPH GGYHSHYHDE GYGPPPPHYE GRRMGPPVGG HRRGPSRYGP QYGHPPPPPP PPEYGPHADS PVLMVYGLDQ SKMNCDRVFN VFCLYGNVEK VKFMKSKPGA AMVEMADGYA VDRAITHLNN NFMFGQKLNV CVSKQPAIMP GQSYGLEDGS CSYKDFSESR NNRFSTPEQA AKNRIQHPSN VLHFFNAPLE VTEENFFEIC DELGVKRPSS VKVFSGKSER SSSGLLEWES KSDALETLGF LNHYQMKNPN GPYPYTLKLC FSTAQHAS; Positive Samples: U-87MG, HeLa, HepG2, A-549, HT-29, Mouse ovary, Rat lung, Rat brain; Cellular Location: Cytoplasm, Nucleus, nucleoplasm.

Heterogeneous nuclear RNAs (hnRNAs) which include mRNA precursors and mature mRNAs are associated with specific proteins to form heterogenous ribonucleoprotein (hnRNP) complexes. Heterogeneous nuclear ribonucleoprotein L is among the proteins that are stably associated with hnRNP complexes and along with other hnRNP proteins is likely to play a major role in the formation, packaging, processing, and function of mRNA. Heterogeneous nuclear ribonucleoprotein L is present in the nucleoplasm as part of the HNRP complex. HNRP proteins have also been identified outside of the nucleoplasm. Exchange of hnRNP for mRNA-binding proteins accompanies transport of mRNA from the nucleus to the cytoplasm. Since HNRP proteins have been shown to shuttle between the nucleus and the cytoplasm, it is possible that they also have cytoplasmic functions. Two transcript variants encoding different isoforms have been found for this gene.

Specifications

• Antigen: hnRNP L
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: HNRNPL
• Gene Alias: C79783; D830027H13Rik; Fblim1; FLJ35509; Heterogeneous nuclear ribonucleoprotein L; heterogenous nuclear ribonucleoprotein L; hnRNP L; Hnrnpl; hnRNP-L; Hnrpl; P/OKcl.14
• Host Species: Rabbit
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 15388, 3191, 80846
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: ELISA, Western Blot, Immunocytochemistry
• Concentration: 2.93 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene Accession No.: F1LQ48, P14866, Q8R081
• Gene Symbols: HNRNPL
• Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 282-589 of human HNRNPL (NP_0015242).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov