Invitrogen™ hnRNP M1-M4 Monoclonal Antibody (1D8)

Mouse Monoclonal Antibody

Supplier:  Invitrogen™ MA116673

Catalog No. AMPA6673

Description

Suggested positive control: antigen standard for HNRNPM (transient overexpression lysate).

Proteins that directly bind to nascent RNA polymerase II transcripts, the heterogenous nuclear ribonucleoproteins (hnRNPs), play an important role in both transcript-specific packaging and alternative splicing of pre-mRNAs. A group of abundant hnRNPs, the M1-M4 proteins, appear as a cluster of four proteins. The M proteins are pre-mRNA binding proteins in vivo, and they bind avidly to poly (G) and poly (U) RNA homopolymers in vitro. M proteins are members of the ribonucleoprotein consensus sequence family of RNA-binding proteins with greatest similarity to a hypothetical RNA-binding protein from Saccharomyces cerevisiae. The M proteins also possess an unusual hexapeptide-repeat region rich in methionine and arginine residues (MR repeat motif) that resembles a repeat in the 64kDa subunit of cleavage stimulation factor, which is involved in 3'-end maturation of pre-mRNAs. Proteins immunologically related to M exist in divergent eukaryotes ranging from human to yeast.

Specifications

• Antigen: hnRNP M1-M4
• Classification: Monoclonal
• Concentration: Conc. Not Determined
• Formulation: ascites with 0.1% sodium azide
• Gene Accession No.: P52272, Q62826, Q9D0E1
• Gene Symbols: HNRNPM
• Immunogen: M19 fusion protein containing full-length human protein.
• Regulatory Status: RUO
• Gene ID (Entrez): 100356502, 100514153, 116655, 4670, 515290, 76936
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot, Immunocytochemistry
• Clone: 1D8
• Conjugate: Unconjugated
• Gene: HNRNPM
• Gene Alias: 2610023M21Rik; AA409009; CEA receptor; CEAR; Heterogeneous nuclear ribonucleoprotein M; heterogenous nuclear ribonucleoprotein M4; hnRNA-binding protein M4; hnRNP M; HNRNP3; Hnrnpm; HNRNPM3; HNRNPM4; HNRPM; Hnrpm4; HTGR1; LOW QUALITY PROTEIN: heterogeneous nuclear ribonucleoprotein M; M4 protein; mKIAA4193; N-acetylglucosamine receptor 1; NAGR1
• Host Species: Mouse
• Quantity: 200 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat, Rabbit, Bovine, Pig
• Product Type: Antibody
• Isotype: IgG1 κ