Invitrogen™ hnRNP M1-M4 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA599438

Catalog No. PIPA599438

Description

Antibody detects endogenous levels of total hnRNP M.

Proteins that directly bind to nascent RNA polymerase II transcripts, the heterogenous nuclear ribonucleoproteins (hnRNPs), play an important role in both transcript-specific packaging and alternative splicing of pre-mRNAs. A group of abundant hnRNPs, the M1-M4 proteins, appear as a cluster of four proteins. The M proteins are pre-mRNA binding proteins in vivo, and they bind avidly to poly (G) and poly (U) RNA homopolymers in vitro. M proteins are members of the ribonucleoprotein consensus sequence family of RNA-binding proteins with greatest similarity to a hypothetical RNA-binding protein from Saccharomyces cerevisiae. The M proteins also possess an unusual hexapeptide-repeat region rich in methionine and arginine residues (MR repeat motif) that resembles a repeat in the 64kDa subunit of cleavage stimulation factor, which is involved in 3'-end maturation of pre-mRNAs. Proteins immunologically related to M exist in divergent eukaryotes ranging from human to yeast.

Specifications

• Antigen: hnRNP M1-M4
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: HNRNPM
• Gene Alias: 2610023M21Rik; AA409009; CEA receptor; CEAR; Heterogeneous nuclear ribonucleoprotein M; heterogenous nuclear ribonucleoprotein M4; hnRNA-binding protein M4; hnRNP M; HNRNP3; Hnrnpm; HNRNPM3; HNRNPM4; HNRPM; Hnrpm4; HTGR1; LOW QUALITY PROTEIN: heterogeneous nuclear ribonucleoprotein M; M4 protein; mKIAA4193; N-acetylglucosamine receptor 1; NAGR1
• Host Species: Rabbit
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 116655, 4670, 76936
• Content And Storage: -20°C
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Concentration: 1 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
• Gene Accession No.: P52272, Q62826, Q9D0E1
• Gene Symbols: HNRNPM
• Immunogen: A synthesized peptide derived from human HNRNPM(Accession P52272), corresponding to amino acid residues G23-A73.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

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