hnRNP M3/4 Mouse anti-Human, Mouse, Clone: 2A6-2H3, Bethyl Laboratories

Mouse Monoclonal Antibody

Supplier:  Bethyl Laboratories, Inc A500011AT

Catalog No. 50-157-1232

Description

The recommended shelf life for this product is 1 year from date of receipt.

Proteins that directly bind to nascent RNA polymerase II transcripts, the heterogenous nuclear ribonucleoproteins (hnRNPs), play an important role in both transcript-specific packaging and alternative splicing of pre-mRNAs. A group of abundant hnRNPs, the M1-M4 proteins, appear as a cluster of four proteins. The M proteins are pre-mRNA binding proteins in vivo, and they bind avidly to poly (G) and poly (U) RNA homopolymers in vitro. M proteins are members of the ribonucleoprotein consensus sequence family of RNA-binding proteins with greatest similarity to a hypothetical RNA-binding protein from Saccharomyces cerevisiae. The M proteins also possess an unusual hexapeptide-repeat region rich in methionine and arginine residues (MR repeat motif) that resembles a repeat in the 64kDa subunit of cleavage stimulation factor, which is involved in 3′-end maturation of pre-mRNAs. Proteins immunologically related to M exist in divergent eukaryotes ranging from human to yeast.

Specifications

• Antigen: hnRNP M3/4
• Classification: Monoclonal
• Conjugate: Unconjugated
• Gene: HNRNPM
• Gene Alias: heterogeneous nuclear ribonucleoprotein M, HNRNPM, HNRNPM4, HNRPM, hnRNA-binding protein M4, HNRNPM3, hnRNA-binding protein M3, HNRNP3, N-acetylglucosamine receptor 1, M4 protein
• Host Species: Mouse
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 4670, 76936
• Content And Storage: 4° C
• Form: Liquid

• Applications: Immunoprecipitation, Western Blot
• Clone: 2A6-2H3
• Formulation: TBS with 0.1% BSA and 0.09% sodium azide
• Gene Accession No.: P52272, Q9D0E1
• Gene Symbols: HNRNPM
• Immunogen: hnRNP M1-4 proteins
• Quantity: 20 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse
• Product Type: Antibody
• Isotype: IgG2b