Invitrogen™ HnRNP Q Polyclonal Antibody

Catalog No.	Quantity
PIPA5121079	100 μL

Catalog No. PIPA5121079 Supplier Invitrogen™ Supplier No. PA5121079

Description

Rabbit Polyclonal Antibody

Positive test controls include: HeLa, Jurkat, A-431, MCF7, BT-474, Mouse heart, Mouse brain, Rat heart. The target is usually found in the following locations: Cytoplasm, Endoplasmic reticulum, Microsome, Nucleus, Nucleus, nucleoplasm. Immunogen sequence: MATEHVNGNG TEEPMDTTSA VIHSENFQTL LDAGLPQKVA EKLDEIYVAG LVAHSDLDER AIEALKEFNE DGALAVLQQF KDSDLSHVQN KSAFLCGVMK TYRQREKQGT KVADSSKGPD EAKIKALLER TGYTLDVTTG QRKYGGPPPD SVYSGQQPSV GTEIFVGKIP RDLFEDELVP LFEKAGPIWD LRLMMDPLTG.

Heterogenous nuclear ribonucleoprotein (hnRNP) implicated in mRNA processing mechanisms. Component of the CRD-mediated complex that promotes MYC mRNA stability. Isoform 1, isoform 2 and isoform 3 are associated in vitro with pre-mRNA, splicing intermediates and mature mRNA protein complexes. Isoform 1 binds to apoB mRNA AU-rich sequences. Isoform 1 is part of the APOB mRNA editosome complex and may modulate the postranscriptional C to U RNA-editing of the APOB mRNA through either by binding to A1CF (APOBEC1 complementation factor), to APOBEC1 or to RNA itself. May be involved in translationally coupled mRNA turnover. Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain. Interacts in vitro preferentially with poly(A) and poly(U) RNA sequences. Isoform 3 may be involved in cytoplasmic vesicle-based mRNA transport through interaction with synaptotagmins. Component of the GAIT (gamma interferon-activated inhibitor of translation) complex which mediates interferon-gamma-induced transcript-selective translation inhibition in inflammation processes. Upon interferon-gamma activation assembles into the GAIT complex which binds to stem loop-containing GAIT elements in the 3'-UTR of diverse inflammatory mRNAs (such as ceruplasmin) and suppresses their translation; seems not to be essential for GAIT complex function.

Specifications

• Antigen: HnRNP Q
• Applications: ELISA, Immunohistochemistry (Paraffin), Western Blot
• Classification: Polyclonal
• Concentration: 0.31 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene: Syncrip
• Gene Accession No.: O60506, Q7TMK9, Q7TP47
• Gene Alias: 2610109K23Rik; 4632417O19Rik; Ab2-339; Glycine- and tyrosine-rich RNA-binding protein; GRYRBP; GRY-RBP; heterogeneous nuclear ribonucleoprotein Q; hnRNP; hnRNP Q; HNRNPQ; hnRNP-Q; HNRPQ; HNRPQ1; liver regeneration-related protein LRRG077; NS1-associated protein 1; NSAP1; Nsap1l; PP68; RRM RNA binding protein GRY-RBP; synaptotagmin binding cytoplasmic RNA interacting protein; synaptotagmin binding, cytoplasmic RNA interacting protein; synaptotagmin-binding, cytoplasmic RNA-interacting protein; Syncrip
• Gene Symbols: Syncrip
• Host Species: Rabbit
• Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-200 of human hnRNP Q /hnRNP Q/SYNCRIP (NP_0011531461).
• Purification Method: Affinity Chromatography
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 10492, 363113, 56403
• Target Species: Human, Mouse, Rat
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG