Invitrogen™ HOPX Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA5114744

Catalog No. PIPA5114744

Description

Antibody detects endogenous levels of total HOP.

HOPX is an atypical homeodomain protein which does not bind DNA and is required to modulate cardiac growth and development. HOPX acts via its interaction with SRF, thereby modulating the expression of SRF-dependent cardiac-specific genes and cardiac development. HOPX prevents SRF-dependent transcription either by inhibiting SRF binding to DNA or by recruiting histone deacetylase (HDAC) proteins that prevent transcription by SRF. HOPX overexpression causes cardiac hypertrophy and may act as a tumor suppressor.

Specifications

• Antigen: HOPX
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: Hopx
• Gene Alias: 1110018K11Rik; 1200015P04Rik; 2300002F06Rik; AI848177; AW490897; Cameo; GIIg15b; global ischemia induced protein GIIG15B; global ischemia-induced gene 15B protein; global ischemia-induced protein 15B; Hdop; HOD; homeobox only domain; homeobox-only protein; homeodomain only protein; homeodomain-only protein; Hop; HOP homeobox; Hopx; LAGY; Lung cancer-associated Y protein; mOB1; NECC1; not expressed in choriocarcinoma clone 1; Not expressed in choriocarcinoma protein 1; OB1; Obl; odd homeobox 1; odd homeobox protein 1; SMAP31; Toto
• Host Species: Rabbit
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 74318, 84525
• Content And Storage: -20°C
• Form: Liquid

• Applications: Immunohistochemistry (PFA fixed), Western Blot
• Concentration: 1 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide
• Gene Accession No.: Q8R1H0, Q9BPY8
• Gene Symbols: Hopx
• Immunogen: A synthesized peptide derived from human HOPX(Accession Q9BPY8), corresponding to amino acid residues A40-D73.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse
• Product Type: Antibody
• Isotype: IgG