Invitrogen™ Hopx Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA590538

Catalog No. PIPA590538

Description

Immunogen sequence: MSAETASGPT EDQVEILEYN FNKVDKHPDS TTLCLIAAEA GLSEEETQKW FKQRLAKWRR SEGLPSECRS VTD; Positive Samples: mouse brain, mouse lung, rat lung; Cellular Location: Nucleus.

HOPX is an atypical homeodomain protein which does not bind DNA and is required to modulate cardiac growth and development. HOPX acts via its interaction with SRF, thereby modulating the expression of SRF-dependent cardiac-specific genes and cardiac development. HOPX prevents SRF-dependent transcription either by inhibiting SRF binding to DNA or by recruiting histone deacetylase (HDAC) proteins that prevent transcription by SRF. HOPX overexpression causes cardiac hypertrophy and may act as a tumor suppressor.

Specifications

• Antigen: Hopx
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: Hopx
• Gene Alias: 1110018K11Rik; 1200015P04Rik; 2300002F06Rik; AI848177; AW490897; Cameo; GIIg15b; global ischemia induced protein GIIG15B; global ischemia-induced gene 15B protein; global ischemia-induced protein 15B; Hdop; HOD; homeobox only domain; homeobox-only protein; homeodomain only protein; homeodomain-only protein; Hop; HOP homeobox; Hopx; LAGY; Lung cancer-associated Y protein; mOB1; NECC1; not expressed in choriocarcinoma clone 1; Not expressed in choriocarcinoma protein 1; OB1; Obl; odd homeobox 1; odd homeobox protein 1; SMAP31; Toto
• Host Species: Rabbit
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 171160, 74318, 84525
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: ELISA, Western Blot, Immunocytochemistry
• Concentration: 2.22 mg/mL
• Formulation: PBS with 50% glycerol and 0.09% sodium azide; pH 7.3
• Gene Accession No.: Q78ZR5, Q8R1H0, Q9BPY8
• Gene Symbols: Hopx
• Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-73 of human HOPX (NP_6319571).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov