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Invitrogen™ HORMAD2 Polyclonal Antibody
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Catalog No. PIPA5139804
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100 μL
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PIPA5139804 100 μL
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Catalog No. PIPA5139804 Supplier Invitrogen™ Supplier No. PA5139804
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Description

Rabbit Polyclonal Antibody

Gently mix before use. Optimal concentrations and conditions for each application should be determined by the user. Immunogen sequence: SHFLLFDKEP INVQVGFVST GFHSMKVKVM TEATKVIDLE NNLFRENSTT EIAHQGLDCD EEEECNDHIQ RMNFVCSQQS SECSRKK Highest antigen sequence indentity to the following orthologs: Mouse - 64%, Rat - 50%.

Essential for synapsis surveillance during meiotic prophase via the recruitment of ATR activity. Plays a key role in the male mid-pachytene checkpoint and the female meiotic prophase checkpoint: required for efficient build-up of ATR activity on unsynapsed chromosome regions, a process believed to form the basis of meiotic silencing of unsynapsed chromatin (MSUC) and meiotic prophase quality control in both sexes. Required for the DNA double-strand break-independent, BRCA1-dependent activation of ATR on the sex chromosomes that is essential for normal sex body formation. [UniProt].
TRUSTED_SUSTAINABILITY

Specifications

Antigen HORMAD2
Applications Immunocytochemistry
Classification Polyclonal
Concentration 0.2 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene HORMAD2
Gene Accession No. Q8N7B1
Gene Alias 4930529M09Rik; CT46.2; HORMA domain containing 2; HORMA domain-containing protein 2; Hormad2
Gene Symbols HORMAD2
Host Species Rabbit
Immunogen Recombinant protein corresponding to Human HORMAD2. Recombinant protein control fragment (Product #RP-108847).
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 150280
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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