Invitrogen™ HOXD11 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA5103895

Catalog No. PIPA5103895

Description

Antibody detects endogenous levels of total HOXD11.

HOX11, also called homeobox11 or Tcl-3 is located at the 10q24 T-Cell translocation breakpoint region. It encodes a homeobox-domain containing protein, HOX11, containing a glycine and proline-rich amino terminus. HOX11 is required for maintenance of the developing spleen and cell survival. The HOX11protein binds to a specific DNA sequence and localizes to the cell nucleus. It transactivates transcription of a reporter gene linked to a cis-regulatory element, acting as a positive transcription activator. The HOX11 gene is highly expressed in T-ALLs as a result of a t (7:10) (q35;q24) or t(10:14)(q24;qll) translocation. The homeobox gene is deregulated upon translocation into the T-cell receptor locus and activates a specific subset of tumor-associated target genes. HOX 11 gene translocation has been attributed to T-cell leukemia and lymphoid neoplasias.

Specifications

• Antigen: HOXD11
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: HOXD11
• Gene Alias: E230017H14Rik; homeo box 4F; homeo box D11; homeobox D11; homeobox protein Hox-4.6; Homeobox protein Hox-4F; homeobox protein Hox-5.5; Homeobox protein Hox-D11; HOX11; HOX4; Hox-4.6; Hox-4.6, mouse, homolog of; HOX4F; Hox-5.4; Hox-5.5; Hoxd11; Hoxd-11; LOC102553842; uncharacterized LOC102553842
• Host Species: Rabbit
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 102553842, 15431, 3237
• Content And Storage: -20°C
• Form: Liquid

• Applications: Western Blot
• Concentration: 1 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
• Gene Accession No.: P23813, P31277
• Gene Symbols: HOXD11
• Immunogen: A synthesized peptide derived from human HOXD11(Accession P31277), corresponding to amino acid residues G206-K256.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

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