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Invitrogen™ HOXA11/HOXD11 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA5101637

Catalog No. PIPA5101637


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Description

Description

Antibody detects endogenous levels of total HOXA11/D11.

HOX11, also called homeobox11 or Tcl-3 is located at the 10q24 T-Cell translocation breakpoint region. It encodes a homeobox-domain containing protein, HOX11, containing a glycine and proline-rich amino terminus. HOX11 is required for maintenance of the developing spleen and cell survival. The HOX11protein binds to a specific DNA sequence and localizes to the cell nucleus. It transactivates transcription of a reporter gene linked to a cis-regulatory element, acting as a positive transcription activator. The HOX11 gene is highly expressed in T-ALLs as a result of a t (7:10) (q35;q24) or t(10:14)(q24;qll) translocation. The homeobox gene is deregulated upon translocation into the T-cell receptor locus and activates a specific subset of tumor-associated target genes. HOX 11 gene translocation has been attributed to T-cell leukemia and lymphoid neoplasias.
TRUSTED_SUSTAINABILITY
Specifications

Specifications

HOXA11/HOXD11
Polyclonal
Unconjugated
HOXD11
E230017H14Rik; homeo box 1I; homeo box 4F; homeo box A11; homeo box D11; homeobox A11; homeobox D11; homeobox protein Hox-1.9; Homeobox protein Hox-1I; homeobox protein Hox-4.6; Homeobox protein Hox-4F; homeobox protein Hox-5.5; homeobox protein HOXA11; Homeobox protein Hox-A11; homeobox protein Hox-D11; HOX1; Hox-1.9; HOX11; HOX1I; HOX4; Hox-4.6; Hox-4.6, mouse, homolog of; HOX4F; Hox-5.4; Hox-5.5; Hoxa11; Hoxa-11; HOXD11; Hoxd-11; LOC102553842; NEWGENE_1564605; RUSAT1; uncharacterized LOC102553842
Rabbit
Affinity Chromatography
RUO
15396, 15431, 3207, 3237
-20°C
Liquid
Western Blot, Immunocytochemistry
1 mg/mL
PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
P23813, P31270, P31277, P31311
HOXA11, HOXD11
A synthesized peptide derived from human HOXA11(Accession P31270), corresponding to amino acid residues P137-P187.
100 μL
Primary
Human, Mouse
Antibody
IgG
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