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Invitrogen™ HOXA11 Polyclonal Antibody
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Catalog No. 01675525
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100 μg
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Catalog No. Quantity
01-675-525 100 μg
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Catalog No. 01-675-525 Supplier Invitrogen™ Supplier No. PA141396
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Description

Rabbit Polyclonal Antibody

Suggested positive control: human, mouse, or rat liver. Predicted to react with Bovine, Chicken, Chimpanzee, Canine and Xenopus. Immunogen sequence: LQNLQPWSDD STK.

HOX11, also called homeobox11 or Tcl-3 is located at the 10q24 T-Cell translocation breakpoint region. It encodes a homeobox-domain containing protein, HOX11, containing a glycine and proline-rich amino terminus. HOX11 is required for maintenance of the developing spleen and cell survival. The HOX11protein binds to a specific DNA sequence and localizes to the cell nucleus. It transactivates transcription of a reporter gene linked to a cis-regulatory element, acting as a positive transcription activator. The HOX11 gene is highly expressed in T-ALLs as a result of a t (7:10) (q35;q24) or t (10:14) (q24;qll) translocation. The homeobox gene is deregulated upon translocation into the T-cell receptor locus and activates a specific subset of tumor-associated target genes. HOX 11 gene translocation has been attributed to T-cell leukemia and lymphoid neoplasias.
TRUSTED_SUSTAINABILITY

Specifications

Antigen HOXA11
Applications Western Blot
Classification Polyclonal
Concentration 0.5 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.2% gelatin and 0.05% sodium azide
Gene HOXA11
Gene Accession No. P31270, P31311
Gene Alias homeo box 1I; homeo box A11; homeobox A11; homeobox protein Hox-1.9; Homeobox protein Hox-1I; homeobox protein HOXA11; homeobox protein Hox-A11; HOX1; Hox-1.9; HOX11; HOX1I; Hoxa11; Hoxa-11; NEWGENE_1564605; RUSAT1
Gene Symbols HOXA11
Host Species Rabbit
Immunogen A peptide sequence corresponding to acids amino acids 306-318 of human HOX11.
Purification Method Protein G
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 103692131, 15396, 3207
Target Species Human, Mouse, Rat
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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