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Invitrogen™ HOXA11 Polyclonal Antibody
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Catalog No. PIPA570380
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100 μL
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PIPA570380 100 μL
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Catalog No. PIPA570380 Supplier Invitrogen™ Supplier No. PA570380
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Description

Rabbit Polyclonal Antibody

This target displays homology in the following species: Cow: 100%; Dog: 100%; Guinea Pig: 85%; Horse: 100%; Human: 100%; Mouse: 100%; Pig: 100%; Rabbit: 100%; Rat: 100%; Sheep: 85%; Zebrafish: 93%.

HOX11, also called homeobox11 or Tcl-3 is located at the 10q24 T-Cell translocation breakpoint region. It encodes a homeobox-domain containing protein, HOX11, containing a glycine and proline-rich amino terminus. HOX11 is required for maintenance of the developing spleen and cell survival. The HOX11protein binds to a specific DNA sequence and localizes to the cell nucleus. It transactivates transcription of a reporter gene linked to a cis-regulatory element, acting as a positive transcription activator. The HOX11 gene is highly expressed in T-ALLs as a result of a t (7:10) (q35;q24) or t (10:14) (q24;qll) translocation. The homeobox gene is deregulated upon translocation into the T-cell receptor locus and activates a specific subset of tumor-associated target genes. HOX 11 gene translocation has been attributed to T-cell leukemia and lymphoid neoplasias.
TRUSTED_SUSTAINABILITY

Specifications

Antigen HOXA11
Applications Western Blot
Classification Polyclonal
Concentration 0.5 mg/mL
Conjugate Unconjugated
Formulation PBS with 2% sucrose and 0.09% sodium azide
Gene HOXA11
Gene Accession No. 0
Gene Alias homeo box 1I; homeo box A11; homeobox A11; homeobox protein Hox-1.9; Homeobox protein Hox-1I; homeobox protein HOXA11; homeobox protein Hox-A11; HOX1; Hox-1.9; HOX11; HOX1I; Hoxa11; Hoxa-11; NEWGENE_1564605; RUSAT1
Gene Symbols HOXA11
Host Species Rabbit
Immunogen synthetic peptide directed towards the middle region of human HOXA11.
Purification Method Affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 103692131
Target Species Rat
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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