Invitrogen™ HOXA13 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA589567

Catalog No. PIPA589567

Description

Immunogen sequence: GPAGPAGAEA AKQCSPCSAA AQSSSGPAAL PYGYFGSGYY PCARMGPHPN AIKSCAQPAS AAAAAAFADK YMDTAGPAAE EFSSRAKEFA FYHQGYAAGP YHHHQPMPGY LDMPVVPGLG GPGESRHEPL GLPMESYQPW ALPNGWNGQM YCPKEQAQPP HLWKSTLPDV VSHPSDASSY R; Positive Samples: 22RV1, HT-29; Cellular Location: Nucleus.

HoxA13 and HoxD13 also bind to other BMP and TGF-beta/Activin-regulated Smad proteins including Smad1 and Smad2, but not Smad4. In humans and mice, loss of HOXA13 function causes defects in the growth and patterning of the digits and interdigital tissues. Analysis of HoxA13 expression reveals a pattern of localization overlapping with sites of reduced Bmp2 and Bmp7 expression in HoxA13 mutant limbs. HoxA13 regulates Bmp2 and Bmp7 expression, providing a link between HoxA13, its target genes and the specific developmental processes affected by loss of HoxA13 function.

Specifications

• Antigen: HOXA13
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: Hoxa13
• Gene Alias: Hd; homeo box 1J; homeo box A13; homeobox A13; homeobox protein Hox-1.10; Homeobox protein Hox-1J; homeobox protein HOXA13; homeobox protein Hox-A13; HOX1; Hox-1.10; HOX1J; HOXA13; hypodactyly; RGD1562483; transcription factor HOXA13
• Host Species: Rabbit
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 3209
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: ELISA, Western Blot
• Concentration: 2.42 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene Accession No.: P31271
• Gene Symbols: Hoxa13
• Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 140-320 of human HOXA13 (NP_0005132).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG