Invitrogen™ HOXB4 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA563440

Catalog No. PIPA563440

Description

Immunogen sequence: CEAVSSSPPP PPCAQNPLHP SPSHSACKEP VVY Highest antigen sequence identity to the following orthologs: Mouse - 97%, Rat - 94%.

HOX homeobox genes play a role both in the early stem cell function as well as in later stages of hematopoietic differentiation. HOXB4, specifically, is a homeotic selector gene implicated in self-renewal of definitive HSCs. Expression of HOXB4 in primitive progenitors combined with culture on hematopoietic stroma induced a switch to the definitive HSC phenotype. Activation of WNT signaling in HSCs induced increased expression of HOXB4. Perturbations of HOX gene expression can cause leukemia.

Specifications

• Antigen: HOXB4
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: HOXB4
• Gene Alias: homeo box 2F; homeo box B4; homeo box B4a; homeobox B4; homeobox B4a; homeobox gene B-4; homeobox protein Hox-2.6; Homeobox protein Hox-2F; homeobox protein Hox-B4; Homeobox protein Hox-B4a; homeobox protein Zf-13; HOX2; Hox-2.6; HOX2F; Hoxb4; HOX-B4; Hoxb-4; Hoxb4 protein; hoxb4a; Hoxb4a variant 2; RGD1560113; sb:eu512; Z-17; zf13; ZF-13
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 3214
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Immunocytochemistry
• Concentration: 0.20 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: P17483
• Gene Symbols: HOXB4
• Immunogen: Recombinant protein corresponding to Human HOXB4. Recombinant protein control fragment (Product #RP-99948).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov