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Invitrogen™ HOXB4 Polyclonal Antibody
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Catalog No. PIPA5116699
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100 μL
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PIPA5116699 100 μL
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Catalog No. PIPA5116699 Supplier Invitrogen™ Supplier No. PA5116699
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Description

Rabbit Polyclonal Antibody

Positive Samples: HL-60, Mouse liver Immunogen sequence: PEAGFGRRAA CTVQRYAACR DPGPPPPPPP PPPPPPPPGL SPRAPAPPPA GALLPEPGQR CEAVSSSPPP PPCAQNPLHP SPSHSACKEP VVYPWMRKVH V.

HOX homeobox genes play a role both in the early stem cell function as well as in later stages of hematopoietic differentiation. HOXB4, specifically, is a homeotic selector gene implicated in self-renewal of definitive HSCs. Expression of HOXB4 in primitive progenitors combined with culture on hematopoietic stroma induced a switch to the definitive HSC phenotype. Activation of WNT signaling in HSCs induced increased expression of HOXB4. Perturbations of HOX gene expression can cause leukemia.
TRUSTED_SUSTAINABILITY

Specifications

Antigen HOXB4
Applications ELISA, Western Blot
Classification Polyclonal
Concentration 1.16 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.01% thimerosal; pH 7.3
Gene HOXB4
Gene Accession No. P10284, P17483
Gene Alias homeo box 2F; homeo box B4; homeo box B4a; homeobox B4; homeobox B4a; homeobox gene B-4; homeobox protein Hox-2.6; Homeobox protein Hox-2F; homeobox protein Hox-B4; Homeobox protein Hox-B4a; homeobox protein Zf-13; HOX2; Hox-2.6; HOX2F; Hoxb4; HOX-B4; Hoxb-4; Hoxb4 protein; hoxb4a; Hoxb4a variant 2; RGD1560113; sb:eu512; Z-17; zf13; ZF-13
Gene Symbols HOXB4
Host Species Rabbit
Immunogen A synthetic peptide corresponding to a sequence within amino acids 50-150 of human HOXB4 (NP_0769201).
Purification Method Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 15412, 3214
Target Species Human, Mouse
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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