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Invitrogen™ HOXD11 Polyclonal Antibody
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Catalog No. PIPA565928
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100 μL
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PIPA565928 100 μL
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Catalog No. PIPA565928 Supplier Invitrogen™ Supplier No. PA565928
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: FDECGQSAASM YLPGCAYYVA PSDFASKPSF LSQPSSCQMT FPYSSNLAP Highest antigen sequence identity to the following orthologs - mouse 98%, rat 98%.

HOX11, also called homeobox11 or Tcl-3 is located at the 10q24 T-Cell translocation breakpoint region. It encodes a homeobox-domain containing protein, HOX11, containing a glycine and proline-rich amino terminus. HOX11 is required for maintenance of the developing spleen and cell survival. The HOX11protein binds to a specific DNA sequence and localizes to the cell nucleus. It transactivates transcription of a reporter gene linked to a cis-regulatory element, acting as a positive transcription activator. The HOX11 gene is highly expressed in T-ALLs as a result of a t (7:10) (q35;q24) or t(10:14)(q24;qll) translocation. The homeobox gene is deregulated upon translocation into the T-cell receptor locus and activates a specific subset of tumor-associated target genes. HOX 11 gene translocation has been attributed to T-cell leukemia and lymphoid neoplasias.
TRUSTED_SUSTAINABILITY

Specifications

Antigen HOXD11
Applications Immunocytochemistry
Classification Polyclonal
Concentration 0.05 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene HOXD11
Gene Accession No. P31277
Gene Alias E230017H14Rik; homeo box 4F; homeo box D11; homeobox D11; homeobox protein Hox-4.6; Homeobox protein Hox-4F; homeobox protein Hox-5.5; Homeobox protein Hox-D11; HOX11; HOX4; Hox-4.6; Hox-4.6, mouse, homolog of; HOX4F; Hox-5.4; Hox-5.5; Hoxd11; Hoxd-11; LOC102553842; uncharacterized LOC102553842
Gene Symbols HOXD11
Host Species Rabbit
Immunogen Recombinant Human HOXD11. Recombinant protein control fragment (Product #RP-106608).
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 3237
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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