Invitrogen™ HOXD11 Polyclonal Antibody

Catalog No.	Quantity
PIPA5144013	100 μg

Catalog No. PIPA5144013 Supplier Invitrogen™ Supplier No. PA5144013

Description

Rabbit Polyclonal Antibody

Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL. Positive Control - WB: human K562 whole cell, human Hek293 whole cell, human U87 whole cell, human A431 whole cell, human A549 whole cell, mouse kidney tissue. IHC: human melanoma tissue, human ovarian cancer tissue, human skin cancer tissue, human testicular cancer tissue. ICC/IF: A431 cell. Flow: 293T cell, NRK cell, RAW2647 cell. Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

HOX11, also called homeobox11 or Tcl-3 is located at the 10q24 T-Cell translocation breakpoint region. It encodes a homeobox-domain containing protein, HOX11, containing a glycine and proline-rich amino terminus. HOX11 is required for maintenance of the developing spleen and cell survival. The HOX11protein binds to a specific DNA sequence and localizes to the cell nucleus. It transactivates transcription of a reporter gene linked to a cis-regulatory element, acting as a positive transcription activator. The HOX11 gene is highly expressed in T-ALLs as a result of a t (7:10) (q35;q24) or t(10:14)(q24;qll) translocation. The homeobox gene is deregulated upon translocation into the T-cell receptor locus and activates a specific subset of tumor-associated target genes. HOX 11 gene translocation has been attributed to T-cell leukemia and lymphoid neoplasias.

Specifications

• Antigen: HOXD11
• Applications: Flow Cytometry, Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Classification: Polyclonal
• Concentration: 500 μg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 4mg trehalose and 0.01mg sodium azide
• Gene: HOXD11
• Gene Accession No.: P23813, P31277
• Gene Alias: E230017H14Rik; homeo box 4F; homeo box D11; homeobox D11; homeobox protein Hox-4.6; Homeobox protein Hox-4F; homeobox protein Hox-5.5; Homeobox protein Hox-D11; HOX11; HOX4; Hox-4.6; Hox-4.6, mouse, homolog of; HOX4F; Hox-5.4; Hox-5.5; Hoxd11; Hoxd-11; LOC102553842; uncharacterized LOC102553842
• Gene Symbols: HOXD11
• Host Species: Rabbit
• Immunogen: A synthetic peptide corresponding to a sequence of human HOXD11 (VREVAFRDYGLERAKWPYR).
• Purification Method: Antigen affinity chromatography
• Quantity: 100 μg
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 102553842, 15431, 3237
• Target Species: Human, Mouse, Rat
• Content And Storage: -20°C
• Product Type: Antibody
• Form: Lyophilized
• Isotype: IgG