Invitrogen™ HP1 beta Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA530416

Catalog No. PIPA530416

Description

Recommended positive controls: HeLa, HepG2, HCT116. Predicted reactivity: Mouse (100%), Xenopus laevis (92%), Chicken (95%), Chimpanzee (100%), Bovine (100%). Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

This gene encodes a highly conserved nonhistone protein, which is a member of the heterochromatin protein family. The protein is enriched in the heterochromatin and associated with centromeres. The protein has a single N-terminal chromodomain which can bind to histone proteins via methylated lysine residues, and a C-terminal chromo shadow-domain which is responsible for the homodimerization and interaction with a number of chromatin-associated nonhistone proteins. The protein may play an important role in the epigenetic control of chromatin structure and gene expression. Several related pseudogenes are located on chromosomes 1, 3, and X. Multiple alternatively spliced variants, encoding the same protein, have been identified.

Specifications

• Antigen: HP1 beta
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: CBX1
• Gene Alias: CBX; Cbx1; Cbx-rs2; chromobox 1; chromobox homolog 1; chromobox homolog 1 (HP1 beta homolog Drosophila ); chromobox protein homolog 1; E430007M08Rik; heterochromatin protein 1 homolog beta; heterochromatin protein 1-beta; heterochromatin protein p25; heterochromatin protein p25 beta; HGNC:1551; HP1 beta; HP1 beta homolog; HP1B; Hp1beta; HP1-BETA; HP1Hsbeta; HP1Hs-beta; M31; MOD1; modifier 1 protein; p25beta
• Host Species: Rabbit
• Purification Method: Antigen Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 10951, 12412
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Concentration: 0.54 mg/mL
• Formulation: 0.1M tris glycine with 20% glycerol and 0.01% thimerosal; pH 7
• Gene Accession No.: P83916, P83917
• Gene Symbols: CBX1
• Immunogen: Recombinant protein fragment corresponding to a region within amino acids 1 and 159 of Human CBX1 / HP1 beta.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse
• Product Type: Antibody
• Isotype: IgG