Invitrogen™ HPD Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA5119747

Catalog No. PIPA5119747

Description

Positive Control: Rat liver tissue lysate, human kidney tissue lysate, rat kidney tissue, human liver tissue, mouse liver tissue. Subcellular Location: Cytosol, endoplasmic reticulum membrane, extracellular exosome, golgi membrane.

The inhibitor of apoptosis (IAP) family of proteins regulates programmed cell death triggered by various stimuli. All IAPs have at least one baculovirus IAP repeat (BIR) motif that is essential for their anti-apoptotic activity (1-3). Recently, a serine protease has been isolated, which is released from the mitochondria upon induction of apoptosis by apoptotic stimuli. This protein called Omi/HtrA2 is a mitochondrial protein that binds to IAP (4). Like Smac/DIABLO, the mature Omi protein contains a conserved IAP-binding motif (AVPS) at its N terminus. The deregulated expression of Omi in the cytoplasm of mammalian cells induces apoptosis indicating that Omi could participate in the mitochondrial apoptotic pathway.

Specifications

• Antigen: HPD
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: Hpd
• Gene Alias: 4H GLOD3; 4-H HPPDASE; 4HPPD; 4-HPPD; 4-hydroxyphenylpyruvate dioxygenase; 4-hydroxyphenylpyruvic acid dioxygenase; 4-hydroxyphenylpyruvic acid oxidase; f Alloantigen; F liver antigen; f protein; Fla; Flp; GLOD3; glyoxalase domain containing 3; HPD; Hppd; HPPDASE; Laf; PPD
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 15445, 29531, 3242
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Concentration: 1 mg/mL
• Formulation: TBS with 0.2% BSA, 50% glycerol and 0.05% sodium azide; pH 7.4
• Gene Accession No.: P32754, P32755, P49429
• Gene Symbols: Hpd
• Immunogen: Recombinant protein within human HPD aa 1-200.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov