Invitrogen™ HPD Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA551249

Catalog No. PA551249

Description

The antibody detects endogenous levels of total HPD protein.

The inhibitor of apoptosis (IAP) family of proteins regulates programmed cell death triggered by various stimuli. All IAPs have at least one baculovirus IAP repeat (BIR) motif that is essential for their anti-apoptotic activity (1-3). Recently, a serine protease has been isolated, which is released from the mitochondria upon induction of apoptosis by apoptotic stimuli. This protein called Omi/HtrA2 is a mitochondrial protein that binds to IAP (4). Like Smac/DIABLO, the mature Omi protein contains a conserved IAP-binding motif (AVPS) at its N terminus. The deregulated expression of Omi in the cytoplasm of mammalian cells induces apoptosis indicating that Omi could participate in the mitochondrial apoptotic pathway.

Specifications

• Antigen: HPD
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: Hpd
• Gene Alias: 4H GLOD3; 4-H HPPDASE; 4HPPD; 4-HPPD; 4-hydroxyphenylpyruvate dioxygenase; 4-hydroxyphenylpyruvic acid dioxygenase; 4-hydroxyphenylpyruvic acid oxidase; f Alloantigen; F liver antigen; f protein; Fla; Flp; GLOD3; glyoxalase domain containing 3; HPD; Hppd; HPPDASE; Laf; PPD
• Host Species: Rabbit
• Purification Method: Antigen Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 15445, 3242
• Content And Storage: -20°C
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Concentration: 1 mg/mL
• Formulation: PBS with 40% glycerol and 0.05% sodium azide; pH 7.4
• Gene Accession No.: P32754, P49429
• Gene Symbols: Hpd
• Immunogen: Fusion protein of human HPD.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse
• Product Type: Antibody
• Isotype: IgG