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Invitrogen™ HPV Type 16 E6 Monoclonal Antibody (HPV-13E2)
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Catalog No. PIMA533324
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100 μg
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PIMA533324 100 μg
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Catalog No. PIMA533324 Supplier Invitrogen™ Supplier No. MA533324
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Description

Mouse Monoclonal Antibody

Monoclonal antibody HPV-13E2 reacts with HPV-16 E6 peptide (MHQKRTAMFQDPPQERPRKLPQLC). Infection with specific types of HPV has been associated with an increased risk of developing cervical neoplasia. HPV types 6 and 11 have been associated with relatively benign diseases such as genital warts but types 16 and 18 are strongly associated with cervical, vaginal, and vulvar malignancies.

Plays a major role in the induction and maintenance of cellular transformation. Acts mainly as an oncoprotein by stimulating the destruction of many host cell key regulatory proteins. E6 associates with host E6-AP ubiquitin-protein ligase, and inactivates tumor suppressors TP53 and TP73 by targeting them to the 26S proteasome for degradation. In turn, DNA damage and chromosomal instabilities increase and lead to cell proliferation and cancer development. The complex E6/E6P targets several other substrates to degradation via the proteasome including host NFX1-91, a repressor of human telomerase reverse transcriptase (hTERT). The resulting increased expression of hTERT prevents the shortening of telomere length leading to cell immortalization. Other cellular targets including Bak, Fas-associated death domain-containing protein (FADD) and procaspase 8, are degraded by E6/E6AP causing inhibition of apoptosis. E6 also inhibits immune response by interacting with host IRF3 and TYK2. These interactions prevent IRF3 transcriptional activities and inhibit TYK2-mediated JAK-STAT activation by interferon alpha resulting in inhibition of the interferon signaling pathway.
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Specifications

Antigen HPV Type 16 E6
Applications ELISA, Immunohistochemistry (Frozen)
Classification Monoclonal
Clone HPV-13E2
Concentration 100 μg/mL
Conjugate Unconjugated
Formulation PBS with 0.02% sodium azide
Gene Alias Human Papillomavirus; Human Papillomavirus 16
Host Species Mouse
Immunogen HPV-16 E6 synthetic peptide.
Purification Method Affinity chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Target Species Virus
Content And Storage 4°C, do not freeze
Product Type Antibody
Form Liquid
Isotype IgG1 κ
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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