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Invitrogen™ HPV Type 16 E7 Monoclonal Antibody (3D6F1)
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Catalog No. PIMA515439
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100 μL
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Catalog No. Quantity
PIMA515439 100 μL
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Catalog No. PIMA515439 Supplier Invitrogen™ Supplier No. MA515439
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Description

Mouse Monoclonal Antibody

MA5-15439 targets E7 in indirect ELISA, WB applications and shows reactivity with Tag samples. The MA5-15439 immunogen is purified recombinant fragment of E7 expressed in E. Coli..

The HPV E7 proteins are small (HPV16 E7 comprising 98 amino acids, 15kDa), zinc binding phosphoproteins which are localised in the nucleus. They are structurally and functionally similar to the E1A protein of subgenus C adenoviruses. The first 16 amino-terminal amino acids of HPV16 E7 contain a region homologous to a segment of the conserved region 1 (CR1) of the E1A protein of subgenus C adenoviruses. The next domain, up to amino acid 37, is homologous to the entire region 2 (CR2) of E1A. Genetic studies have established that these domains are required for cell transformation in vitro, suggesting similarities in the mechanism of transformation by these viruses. The CR2 homology region contains the LXCXE motif (residues 22-26) involved in binding to the tumour suppressor protein pRb.
TRUSTED_SUSTAINABILITY

Specifications

Antigen HPV Type 16 E7
Applications ELISA, Western Blot
Classification Monoclonal
Clone 3D6F1
Concentration Conc. Not Determined
Conjugate Unconjugated
Formulation Ascites with 0.03% sodium azide
Gene Alias HPV 16-E7; HPV16E7; human papillomavirus
Host Species Mouse
Immunogen Purified recombinant full-lenght E7 expressed in E. Coli.
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Target Species Virus
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG1
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