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Invitrogen™ HPV Type 16 E7 Monoclonal Antibody (716-325)
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Catalog No. PIMA123087
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250 μg
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PIMA123087 250 μg
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Catalog No. PIMA123087 Supplier Invitrogen™ Supplier No. MA123087
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Description

Mouse Monoclonal Antibody

MA1-23087 detects HPV-16 in Virus samples.

The HPV E7 proteins are small (HPV16 E7 comprising 98 amino acids, 15kDa), zinc binding phosphoproteins which are localised in the nucleus. They are structurally and functionally similar to the E1A protein of subgenus C adenoviruses. The first 16 amino-terminal amino acids of HPV16 E7 contain a region homologous to a segment of the conserved region 1 (CR1) of the E1A protein of subgenus C adenoviruses. The next domain, up to amino acid 37, is homologous to the entire region 2 (CR2) of E1A. Genetic studies have established that these domains are required for cell transformation in vitro, suggesting similarities in the mechanism of transformation by these viruses. The CR2 homology region contains the LXCXE motif (residues 22-26) involved in binding to the tumour suppressor protein pRb.
TRUSTED_SUSTAINABILITY

Specifications

Antigen HPV Type 16 E7
Applications ELISA, Western Blot
Classification Monoclonal
Clone 716-325
Concentration 3.6 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.09% sodium azide; pH 7.2
Gene Alias HPV 16-E7; HPV16E7; human papillomavirus
Host Species Mouse
Immunogen HPV oncoprotein E7, type 16.
Purification Method Protein G
Quantity 250 μg
Regulatory Status RUO
Primary or Secondary Primary
Target Species Virus
Content And Storage 4°C
Product Type Antibody
Form Liquid
Isotype IgG2a
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