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Invitrogen™ HRG beta-1 Polyclonal Antibody, PeproTech®, Invitrogen™

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ 500P288100UG

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Catalog No. 500P288100


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Description

Description

AA Sequence of recombinant protein: SHLVKCAEKE KTFCVNGGEC FMVKDLSNPS RYLCKCPNEF TGDRCQNYVM ASFYKHLGIE FMEAE. Preparation: Produced from sera of rabbits immunized with highly pure Recombinant Human Heregulinbeta-1. Anti-Human Heregulinbeta-1-specific antibody was purified by affinity chromatography employing an immobilized Human Heregulinbeta-1 matrix. Sandwich ELISA: To detect Human Heregulinbeta-1 by sandwich ELISA (using 100 μL/well antibody solution) a concentration of 0.5-2.0 μg/mL of this antibody is required. This antigen affinity purified antibody, in conjunction with PeproTech Biotinylated Anti-Human Heregulinbeta- 1 (500-P288Bt) as a detection antibody, allows the detection of at least 0.2-0.4 ng/well of Recombinant Human Heregulinbeta-1. Western Blot: To detect Human Heregulin-beta1 by Western Blot analysis this antibody can be used at a concentration of 0.1-0.2 μg/mL. When used in conjunction with compatible secondary reagents, the detection limit for Recombinant Human Heregulin-beta1 is 1.5-3.0 ng/lane, under either reducing or non-reducing conditions.

Direct ligand for ERBB3 and ERBB4 tyrosine kinase receptors. Concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. The multiple isoforms perform diverse functions such as inducing growth and differentiation of epithelial, glial, neuronal, and skeletal muscle cells; inducing expression of acetylcholine receptor in synaptic vesicles during the formation of the neuromuscular junction; stimulating lobuloalveolar budding and milk production in the mammary gland and inducing differentiation of mammary tumor cells; stimulating Schwann cell proliferation; implication in the development of the myocardium such as trabeculation of the developing heart. Isoform 10 may play a role in motor and sensory neuron development.
TRUSTED_SUSTAINABILITY
Specifications

Specifications

HRG beta-1
Polyclonal
Unconjugated
Nrg1
6030402G23Rik; acetylcholine receptor-inducing activity; ARIA; Breast cancer cell differentiation factor p45; D230005F13Rik; GGF; GGF2; GGFII; Glial growth factor; glial growth factor 2; heregulin; heregulin, alpha (45kD, ERBB2 p185-activator); Hgl; HRG; HRG1; HRGA; HRGalpha; MST131; MSTP131; NDF; Neu differentiation factor; neuregulin 1; neuregulin 1 type III beta 3; Neuregulin-1; Nrg1; NRG1-IT2; Pro-neuregulin-1, membrane-bound isoform; pro-NRG1; sensory and motor neuron derived factor; Sensory and motor neuron-derived factor; SMDF; type I neuregulin 1; type III neuregulin 1
Rabbit
Antigen affinity chromatography
RUO
3084
-20°C
Lyophilized
ELISA, Western Blot
0.1-1.0 mg/mL
PBS with no preservative
Q02297
Nrg1
E.coli-derived Recombinant Human Heregulinbeta-1.
100 μg
Primary
Human
Antibody
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