HRH4 Polyclonal Antibody, Invitrogen™

Rabbit Polyclonal Antibody

Supplier:  Thermo Scientific PA521313

Catalog No. PIPA521313

Description

Recommended positive controls: Jurkat, Raji, NCI-H929, 293T, A431, HeLa, HepG2. Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

The Histamine H4 receptor has been reported in human blood peripheral leukocytes, bone marrow, colon, liver, lung, smalll intestine, spleen, testis, thymus, tonsil, and trachea. Contrary to the mouse H4 receptor, the human gene was not detected in brain. G-protein Coupled Receptors (GPCRs) comprise one of the largest families of signaling molecules with more thana thousandmembers currently predicted to exist. All GPCRs share a structural motif consisting of seven membrane-spanning helices, and exist in both active and inactive forms. An array of activating ligands participate in the conformation of GPCRs which leads to signaling via G-proteins and downstream effectors. Ongoing studies have also shown the vast series of reactions which participate in the negative regulation of GPCRs. This "e;turn-off"e; activity has tremendous implications for the physiological action of the cell, and continues to drive pharmacological research for new drug candidates. Twoblockbuster drugs which have been developed as GPCR-targetedpharmaceuticals are Zyprexa (Eli Lilly) and Claritin (Schering-Plough) which have multi-billion dollar shares of the mental health and allergy markets, respectively.

Specifications

• Antigen: HRH4
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: HRH4
• Gene Alias: AXOR35; BG26; GPCR105; Gprc105; G-protein coupled receptor 105; GPRv53; H4; H4R; HH4R; histamine H4 receptor; histamine receptor; histamine receptor H4; Hrh4; MGC130500; Pfi-013; SP9144
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 59340
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Western Blot
• Concentration: 1 mg/mL
• Formulation: PBS with 50% glycerol and 0.01% thimerosal; pH 7
• Gene Accession No.: Q9H3N8
• Gene Symbols: HRH4
• Immunogen: Synthetic peptide corresponding to a region within amino acids 1 and 82 of Histamine H4 Receptor (Uniprot ID#Q9H3N8)
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG