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Invitrogen™ HRH4 Polyclonal Antibody
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Catalog No. OPA115360
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25 μg
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OPA115360 25 μg
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Catalog No. OPA115360 Supplier Invitrogen™ Supplier No. OPA115360
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Description

Rabbit Polyclonal Antibody

By immunohistochemistry, OPA1-15360 detects the Histamine H4 receptor in formalin fixed, paraffin embedded human tissues.

The Histamine H4 receptor has been reported in human blood peripheral leukocytes, bone marrow, colon, liver, lung, smalll intestine, spleen, testis, thymus, tonsil, and trachea. Contrary to the mouse H4 receptor, the human gene was not detected in brain. G-protein Coupled Receptors (GPCRs) comprise one of the largest families of signaling molecules with more thana thousandmembers currently predicted to exist. All GPCRs share a structural motif consisting of seven membrane-spanning helices, and exist in both active and inactive forms. An array of activating ligands participate in the conformation of GPCRs which leads to signaling via G-proteins and downstream effectors. Ongoing studies have also shown the vast series of reactions which participate in the negative regulation of GPCRs. This 'turn-off' activity has tremendous implications for the physiological action of the cell, and continues to drive pharmacological research for new drug candidates. Twoblockbuster drugs which have been developed as GPCR-targetedpharmaceuticals are Zyprexa (Eli Lilly) and Claritin (Schering-Plough) which have multi-billion dollar shares of the mental health and allergy markets, respectively.
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Specifications

Antigen HRH4
Applications Immunohistochemistry (Paraffin), Immunocytochemistry
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.1% sodium azide
Gene HRH4
Gene Accession No. Q9H3N8
Gene Alias AXOR35; BG26; GPCR105; Gprc105; G-protein coupled receptor 105; GPRv53; H4; H4R; HH4R; histamine H4 receptor; histamine receptor; histamine receptor H4; Hrh4; MGC130500; Pfi-013; SP9144
Gene Symbols HRH4
Host Species Rabbit
Immunogen Synthetic 18 amino acid peptide from 1st cytoplasmic domain of human HRH4/Histamine H4 Receptor.
Purification Method Antigen affinity chromatography
Quantity 25 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 59340
Target Species Human, Monkey
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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