HRH4 Rabbit anti-Mouse∣Rat, Polyclonal, Bioss

Catalog No.	Quantity
50-198-1013	100 μL

Catalog No. 50-198-1013 Supplier Bioss Supplier No. BS10993R

Description

Rabbit Polyclonal Antibody

The Histamine H4 receptor has been reported in human blood peripheral leukocytes, bone marrow, colon, liver, lung, smalll intestine, spleen, testis, thymus, tonsil, and trachea. Contrary to the mouse H4 receptor, the human gene was not detected in brain. G-protein Coupled Receptors (GPCRs) comprise one of the largest families of signaling molecules with more thana thousandmembers currently predicted to exist. All GPCRs share a structural motif consisting of seven membrane-spanning helices, and exist in both active and inactive forms. An array of activating ligands participate in the conformation of GPCRs which leads to signaling via G-proteins and downstream effectors. Ongoing studies have also shown the vast series of reactions which participate in the negative regulation of GPCRs. This 'turn-off' activity has tremendous implications for the physiological action of the cell, and continues to drive pharmacological research for new drug candidates. Twoblockbuster drugs which have been developed as GPCR-targetedpharmaceuticals are Zyprexa (Eli Lilly) and Claritin (Schering-Plough) which have multi-billion dollar shares of the mental health and allergy markets, respectively.

Specifications

• Antigen: HRH4
• Applications: Western Blot
• Classification: Polyclonal
• Concentration: 1 μg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 1% BSA, 50% glycerol and 0.09% sodium azide; pH
• Gene: HRH4
• Gene Accession No.: Q91ZY1, Q91ZY2
• Gene Alias: AXOR35; BG26; GPCR105; Gprc105; G-protein coupled receptor 105; GPRv53; H4; H4R; HH4R; Histamine H4 receptor; histamine receptor H4; HRH4; MGC130500; Pfi-013; SP9144
• Gene Symbols: HRH4
• Host Species: Rabbit
• Immunogen: KLH conjugated synthetic peptide derived from mouse HRH4.
• Purification Method: Protein A
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 170704, 225192
• Target Species: Mouse, Rat
• Content And Storage: -20°C
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG