Invitrogen™ HRI Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA582551

Catalog No. PIPA582551

Description

Immunogen sequence: PDPEYDESDV PAEIQVLKEP LQQPTFPFAV ANQLLLVSLL EHLSHVHEPN PLRSRQVFKL LCQTFIKMGL LSSFTCSDEF SSLRLHHNRA ITHLMRSAKE RVRQDPCEDI SRIQKIRSRE VALEAQTSRY LNEFEELAIL GKGGYGR.

EIF2AK1 (HRI) is one of 4 kinases that specifically phosphorylate Ser51 of translation initiation factor eIF2-alpha in response to various environmental stresses, leading to a decrease in protein sythesis. In the case of EIF2AK1, signaling is initiated by low levels of heme. The HRI gene is localized to 7p22 where its 3' end slightly overlaps the 3' end of the gene JTV1. The two genes are transcribed from opposite strands and kinase activity is induced by low levels of heme and inhibited by the presence of heme.

Specifications

• Antigen: HRI
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: EIF2AK1
• Gene Alias: EIF2AK1; eukaryotic translation initiation factor 2 alpha kinase 1; eukaryotic translation initiation factor 2-alpha kinase 1; HCR; he; heme regulated initiation factor 2 alpha kinase; heme sensitive initiation factor 2a kinase; heme-controlled repressor; Heme-regulated eukaryotic initiation factor eIF-2-alpha kinase; heme-regulated inhibitor; heme-regulated initiation factor 2-alpha kinase; heme-regulated repressor; hemin-sensitive initiation factor 2a kinase; hemin-sensitive initiation factor 2-alpha kinase; Hri; KIAA1369; PRO1362
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 27102
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Concentration: 0.2 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: Q9BQI3
• Gene Symbols: EIF2AK1
• Immunogen: Recombinant protein corresponding to Human EIF2AK1. Recombinant protein control fragment (Product #RP-91431).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov