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Invitrogen™ HRK Polyclonal Antibody
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Catalog No. PIPA5107146
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100 μL
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PIPA5107146 100 μL
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Catalog No. PIPA5107146 Supplier Invitrogen™ Supplier No. PA5107146
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Description

Rabbit Polyclonal Antibody

Sequence homology: Cow: 100%; Dog: 100%; Human: 100%; Mouse: 83%; Rabbit: 100%; Rat: 83%.

Apoptosis plays a major role in normal organism development, tissue homeostasis, and removal of damaged cells. Hrk, a pro-apoptotic member of the Bcl-2 homology domain-3 (BH3)-only group of the Bcl-2 family of proteins, was also identified as novel protein induced during programmed neuronal death. It lacks significant homology to other Bcl-2 family members except for an 8-amino acid region that is similar to the BH3 motif of Bik. Hrk regulates apoptosis through interaction with the anti-apoptotic proteins Bcl-2 and Bcl-XL via this domain. It does not interact with the pro-apoptotic proteins Bax, Bak, or Bcl-XS. Hrk localizes to mitochondrial membranes in a pattern similar to that previously reported for Bcl-2 and Bcl-XL.
TRUSTED_SUSTAINABILITY

Specifications

Antigen HRK
Applications Western Blot
Classification Polyclonal
Concentration 0.5 mg/mL
Conjugate Unconjugated
Formulation PBS with 2% sucrose and 0.09% sodium azide; pH 7.4
Gene HRK
Gene Accession No. O00198
Gene Alias Activator of apoptosis harakiri; activator of apoptosis Hrk; AI838259; BCL2-interacting protein; BH3 interacting (with BCL2 family) domain, apoptosis agonist; BH3-interacting domain-containing protein 3; Bid3; death protein 5; DP5; harakiri; harakiri, BCL2 interacting protein; harakiri, BCL2 interacting protein (contains only BH3 domain); Hrk; Neuronal death protein DP5
Gene Symbols HRK
Host Species Rabbit
Immunogen Synthetic peptide directed towards the N terminal region of human HRK (aa 1-51).
Purification Method Affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 8739
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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