Invitrogen™ HRK Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA520235

Catalog No. PIPA520235

Description

Despite its predicted molecular weight, Hrk often migrates at 12-15kDa in SDS-PAGE. A suggested positive control is mouse pancreas tissue lysate. PA5-20235 can be used with blocking peptide PEP-0369.

Apoptosis plays a major role in normal organism development, tissue homeostasis, and removal of damaged cells. Hrk, a pro-apoptotic member of the Bcl-2 homology domain-3 (BH3)-only group of the Bcl-2 family of proteins, was also identified as novel protein induced during programmed neuronal death. It lacks significant homology to other Bcl-2 family members except for an 8-amino acid region that is similar to the BH3 motif of Bik. Hrk regulates apoptosis through interaction with the anti-apoptotic proteins Bcl-2 and Bcl-XL via this domain. It does not interact with the pro-apoptotic proteins Bax, Bak, or Bcl-XS. Hrk localizes to mitochondrial membranes in a pattern similar to that previously reported for Bcl-2 and Bcl-XL.

Specifications

• Antigen: HRK
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: HRK
• Gene Alias: Activator of apoptosis harakiri; activator of apoptosis Hrk; AI838259; BCL2-interacting protein; BH3 interacting (with BCL2 family) domain, apoptosis agonist; BH3-interacting domain-containing protein 3; Bid3; death protein 5; DP5; harakiri; harakiri, BCL2 interacting protein; harakiri, BCL2 interacting protein (contains only BH3 domain); Hrk; Neuronal death protein DP5
• Host Species: Rabbit
• Purification Method: Antigen Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 12123, 8739
• Content And Storage: Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
• Form: Liquid

• Applications: Western Blot
• Concentration: 1 mg/mL
• Formulation: PBS with 0.02% sodium azide
• Gene Accession No.: O00198, P62816
• Gene Symbols: HRK
• Immunogen: A 15 amino acid peptide from near the center of human Hrk.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human, Mouse
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov