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Invitrogen™ HRK Polyclonal Antibody
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Catalog No. PIPA520235
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100 μg
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Catalog No. Quantity
PIPA520235 100 μg
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Catalog No. PIPA520235 Supplier Invitrogen™ Supplier No. PA520235
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Description

Rabbit Polyclonal Antibody

Despite its predicted molecular weight, Hrk often migrates at 12-15kDa in SDS-PAGE. A suggested positive control is mouse pancreas tissue lysate. PA5-20235 can be used with blocking peptide PEP-0369.

Apoptosis plays a major role in normal organism development, tissue homeostasis, and removal of damaged cells. Hrk, a pro-apoptotic member of the Bcl-2 homology domain-3 (BH3)-only group of the Bcl-2 family of proteins, was also identified as novel protein induced during programmed neuronal death. It lacks significant homology to other Bcl-2 family members except for an 8-amino acid region that is similar to the BH3 motif of Bik. Hrk regulates apoptosis through interaction with the anti-apoptotic proteins Bcl-2 and Bcl-XL via this domain. It does not interact with the pro-apoptotic proteins Bax, Bak, or Bcl-XS. Hrk localizes to mitochondrial membranes in a pattern similar to that previously reported for Bcl-2 and Bcl-XL.
TRUSTED_SUSTAINABILITY

Specifications

Antigen HRK
Applications Western Blot
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.02% sodium azide
Gene HRK
Gene Accession No. O00198, P62816
Gene Alias Activator of apoptosis harakiri; activator of apoptosis Hrk; AI838259; BCL2-interacting protein; BH3 interacting (with BCL2 family) domain, apoptosis agonist; BH3-interacting domain-containing protein 3; Bid3; death protein 5; DP5; harakiri; harakiri, BCL2 interacting protein; harakiri, BCL2 interacting protein (contains only BH3 domain); Hrk; Neuronal death protein DP5
Gene Symbols HRK
Host Species Rabbit
Immunogen A 15 amino acid peptide from near the center of human Hrk.
Purification Method Antigen Affinity Chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 12123, 8739
Target Species Human, Mouse
Content And Storage Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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