Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More
  1. Home
  2. Products
  3. Antibodies
  4. Primary Antibodies
  5. All Primary Antibodies
  6. PIMA524265

Invitrogen™ HS6ST1 Monoclonal Antibody (584308)
GREENER_CHOICE

Catalog No. PIMA524265
Change view
Click to view available options
Quantity:
100 μg
1 product options available for selection
Product selection table with 1 available options. Use arrow keys to navigate and Enter or Space to select.
Catalog No. Quantity
PIMA524265 100 μg
Use arrow keys to navigate between rows. Press Enter or Space to select a product option. 1 options available.
1 options
Catalog No. PIMA524265 Supplier Invitrogen™ Supplier No. MA524265
Add to Cart
Add to Cart

Description

Mouse Monoclonal Antibody

Reconstitute at 0.5 mg/mL in sterile PBS.

The HS6ST1 gene encodes the enzyme heparan sulfate 6-O-sulfotransferase 1, which is essential for the biosynthesis of heparan sulfate (HS) glycosaminoglycans by adding sulfate groups to the 6th position of glucosamine residues within HS chains. HS6ST1 is vital for numerous biological processes, including modulating the activity of growth factors, cytokines, and chemokines, which are influenced by HS structures on the cell surface and extracellular matrix. This sulfation step is critical for the proper functioning of developmental pathways and neuronal signaling, impacting brain development and function. Mutations in HS6ST1 have been associated with intellectual disabilities and developmental disorders such as hypogonadotropic hypogonadism and Kallmann syndrome, characterized by impaired sense of smell and delayed puberty. Moreover, altered HS6ST1 expression is implicated in cancer progression by affecting tumor growth, angiogenesis, and metastasis through altered HS interactions with signaling molecules. Its role in modulating receptor-ligand interactions makes HS6ST1 a promising target for therapeutic interventions aimed at repairing defective signaling pathways associated with genetic disorders and cancer.
TRUSTED_SUSTAINABILITY

Specifications

Antigen HS6ST1
Applications Immunohistochemistry (Paraffin)
Classification Monoclonal
Clone 584308
Concentration 0.5 mg/mL
Conjugate Unconjugated
Formulation PBS with 5% trehalose and No Preservative
Gene HS6ST1
Gene Accession No. O60243
Gene Alias 6Ost1; heparan sulfate 6-O-sulfotransferase 1; heparan-sulfate 6-O-sulfotransferase 1; heparan-sulfate 6-sulfotransferase; HH15; HS6ST; HS6ST1; HS6ST-1; mHS6ST-1
Gene Symbols HS6ST1
Host Species Mouse
Immunogen CHO-derived recombinant human Heparan Sulfate 6-O-Sulfotransferase 1/HS6ST1 Pro38-Trp411.
Purification Method Protein A/G
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 9394
Target Species Human
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Lyophilized
Isotype IgG2a
Show More Show Less
Product Title
Select an issue

By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.