Invitrogen™ HS6ST1 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA5111203

Catalog No. PIPA5111203

Description

Immunogen sequence: QRYQYKRQLE RREQRLRSRE ERLLHRAKEA LPREDADEPG RVPTEDYMSH IIEKW.

The HS6ST1 gene encodes the enzyme heparan sulfate 6-O-sulfotransferase 1, which is essential for the biosynthesis of heparan sulfate (HS) glycosaminoglycans by adding sulfate groups to the 6th position of glucosamine residues within HS chains. HS6ST1 is vital for numerous biological processes, including modulating the activity of growth factors, cytokines, and chemokines, which are influenced by HS structures on the cell surface and extracellular matrix. This sulfation step is critical for the proper functioning of developmental pathways and neuronal signaling, impacting brain development and function. Mutations in HS6ST1 have been associated with intellectual disabilities and developmental disorders such as hypogonadotropic hypogonadism and Kallmann syndrome, characterized by impaired sense of smell and delayed puberty. Moreover, altered HS6ST1 expression is implicated in cancer progression by affecting tumor growth, angiogenesis, and metastasis through altered HS interactions with signaling molecules. Its role in modulating receptor-ligand interactions makes HS6ST1 a promising target for therapeutic interventions aimed at repairing defective signaling pathways associated with genetic disorders and cancer.

Specifications

• Antigen: HS6ST1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: HS6ST1
• Gene Alias: 6Ost1; heparan sulfate 6-O-sulfotransferase 1; heparan-sulfate 6-O-sulfotransferase 1; heparan-sulfate 6-sulfotransferase; HH15; HS6ST; HS6ST1; HS6ST-1; mHS6ST-1
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 9394
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Western Blot, Immunocytochemistry
• Concentration: 0.4 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: O60243
• Gene Symbols: HS6ST1
• Immunogen: Recombinant Protein corresonding to Human HS6ST1. Recombinant protein control fragment (Product #RP-96091).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov