HSC70 Rabbit anti-Human, Mouse, Zebrafish, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Supplier:  Thermo Scientific PA572679

Catalog No. PIPA572679

Description

Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis and ADP release, mediated by co-chaperones. The affinity of HSP70 for polypeptides is regulated by its nucleotide bound state. In the ATP-bound form, it has a low affinity for substrate proteins. However, upon hydrolysis of the ATP to ADP, it undergoes a conformational change that increases its affinity for substrate proteins. HSP70 goes through repeated cycles of ATP hydrolysis and nucleotide exchange, which permits cycles of substrate binding and release. {ECO:0000250 UniProtKB:P11142}.

Specifications

• Antigen: HSC70
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: HSPA8
• Gene Alias: HSPA8 ; heat shock 70kDa protein 8 ; HSC54; HSC70; HSC71; HSP71; HSP73; HSPA10; LAP; MGC131511; MGC29929; NIP71 ; LPS-associated protein 1; N-myristoyltransferase inhibitor protein 71; constitutive heat shock protein 70; heat shock 70kD protein 8; heat shock 70kd protein 10; heat shock cognate protein 54; heat shock cognate protein; 71-kDa; lipopolysaccharide-associated protein ; uncharacterized bone marrow protein BM034
• Host Species: Rabbit
• Purification Method: Protein A
• Regulatory Status: RUO
• Gene ID (Entrez): 15481, 3312, 573376
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Western Blot
• Concentration: 0.66 mg/mL
• Formulation: PBS with 0.09% sodium azide
• Gene Accession No.: P11142, P63017, Q90473
• Gene Symbols: HSPA8
• Immunogen: KLH conjugated synthetic peptide between 458-490 amino acids from the C-terminal region of DANRE hspa8
• Quantity: 50 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Zebrafish
• Product Type: Antibody
• Isotype: IgG