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HSD11B1 Polyclonal Antibody, Invitrogen™

Catalog No. PIPA521586
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PIPA521586 100 μL
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Catalog No. PIPA521586 Supplier Thermo Scientific Supplier No. PA521586

Description

Rabbit Polyclonal Antibody

Recommended positive controls: HepG2. Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

HSD11B1 is a microsomal enzyme that catalyzes the conversion of the stress hormone cortisol to the inactive metabolite cortisone. In addition, HSD11B1 can catalyze the reverse reaction, the conversion of cortisone to cortisol. Too much cortisol can lead to central obesity, and a particular variation in this gene has been associated with obesity and insulin resistance in children. The protein encoded by this gene is a microsomal enzyme that catalyzes the conversion of the stress hormone cortisol to the inactive metabolite cortisone. In addition, the encoded protein can catalyze the reverse reaction, the conversion of cortisone to cortisol. Too much cortisol can lead to central obesity, and a particular variation in this gene has been associated with obesity and insulin resistance in children. Two transcript variants encoding the same protein have been found for this gene.
TRUSTED_SUSTAINABILITY

Specifications

Antigen HSD11B1
Applications Immunocytochemistry, Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.01% thimerosal; pH 7
Gene Hsd11b1
Gene Accession No. P16232, P28845, P50172, P51975
Gene Alias 11 beta-hydroxysteroid dehydrogenase type 1; 11beta-HSD type 1; 11-beta-HSD1; 11beta-HSD1; 11beta-HSD-1; 11beta-HSD1A; 11-beta-hydroxysteroid dehydrogenase; 11-beta-hydroxysteroid dehydrogenase 1; 11-beta-hydroxysteroid dehydrogenase type 1; 11beta-hydroxysteroid dehydrogenase type 1; 11-DH; Corticosteroid 11-beta-dehydrogenase isozyme 1; Corticosteroid 11-beta-dehydrogenase, isozyme 1 (11-DH) (11-beta-hydroxysteroid dehydrogenase 1) (11-beta-HSD1) (11beta-HSD1A); cortocosteroid 11-beta dehydrogenase; CORTRD2; HDL; HSD11; HSD11B; Hsd11b1; HSD11L; hydroxysteroid (11-beta) dehydrogenase 1; hydroxysteroid 11-beta dehydrogenase 1; hydroxysteroid dehydrogenase, 11 beta type 1; LRRGT00065; MGC13539; OTTHUMP00000034650; SDR26C1; short chain dehydrogenase/reductase family 26C member 1; short chain dehydrogenase/reductase family 26C, member 1; short-chain reductase; short-chain reductase/dehydrogenase
Gene Symbols Hsd11b1
Host Species Rabbit
Immunogen Synthetic peptide corresponding to a region within amino acids 232 and 292 of HSD11B1
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 15483, 25116, 3290, 443409
Target Species Human, Mouse, Ovine, Rat
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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