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MilliporeSigma™ HSD17B3, Mouse, Unlabeled, Clone: 3E11.2,

Catalog No. MABS1165MI Shop All MilliporeSigma Products
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Quantity:
100 μL
Conjugate:
Unconjugated
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Catalog No. Quantity Conjugate
MABS1165MI 100 μL Unconjugated
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Catalog No. MABS1165MI Supplier MilliporeSigma™ Supplier No. MABS1165
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Description

Mouse Monoclonal Antibody

Testosterone 17-beta-dehydrogenase 3 (EC 1.1.1.64; UniProt P37058; also known as 17-beta-HSD 3, 17-beta-hydroxysteroid dehydrogenase type 3, Short chain dehydrogenase/reductase family 12C member 2, Testicular 17-beta-hydroxysteroid dehydrogenase) is encoded by the HSD17B3 (also known as EDH17B3, SDR12C2) gene (Gene ID 3293) in human. 17 -hydroxysteroid dehydrogenases (17 -HSDs) mediate the activation and deactivation of sex steroids involving redox reactions centered about the C17 area of the steroid backbone. 17 -HSD3 catalyzes the final step in the steroidogenesis of the potent androgen testosterone (T) by selectively reducing the C17 ketone of 4-dione, utilizing NADPH as a cofactor, in testis and prostate. Upregulated 17 -HSD3 mRNA level is found in cancerous prostate biopsies when compared to normal tissue, while 17 -HSD3 deficiency caused by HSD17B3 gene mutations results in 46,XY Disorders of Sex Development (46,XY DSD).
TRUSTED_SUSTAINABILITY

Specifications

Antigen HSD17B3
Applications Western Blot
Classification Monoclonal
Clone 3E11.2
Concentration Please refer to lot specific datasheet.
Conjugate Unconjugated
Formulation Purified mouse monoclonal antibody IgG2b in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% Sodium Azide.
Gene HSD17B3, EDH17B3, SDR12C2
Gene Accession No. P37058
Host Species Mouse
Immunogen KLH-conjugated linear peptide corresponding to an internal sequence within the N-terminal half of human HSD17B3.
Purification Method Protein G Purified
Quantity 100 μL
Regulatory Status RUO
Research Discipline Signaling
Primary or Secondary Primary
Gene ID (Entrez) NP_000188
Test Specificity Clone 3E11.2 targets an epitope within the N-terminal half of mouse HSD17B3 and the two human spliced isoforms reported by UniProt (P70385 and P37058).
Target Species Mouse
Content And Storage Stable for 1 year at 2°-8°C from date of receipt.
Form Purified
Isotype IgG2b κ
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For Research Use Only. Not for use in diagnostic procedures.

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