Invitrogen™ HSD17B4 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA521522

Catalog No. PIPA521522

Description

Recommended positive controls: Rat heart. Predicted reactivity: Mouse (87%), Rat (88%), Pig (88%), Bovine (88%), Guinea pig (84%). Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Peroxisomal multifunctional enzyme type 2 is a protein that in humans is encoded by the HSD17B4 gene. The protein encoded by this gene is a bifunctional enzyme that is involved in the peroxisomal beta-oxidation pathway for fatty acids. It also acts as a catalyst for the formation of 3-ketoacyl-CoA intermediates from both straight-chain and 2-methyl-branched-chain fatty acids. Defects in this gene that affect the peroxisomal fatty acid beta-oxidation activity are a cause of D-bifunctional protein deficiency (DBPD). An apparent pseudogene of this gene is present on chromosome 8. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.

Specifications

• Antigen: HSD17B4
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: HSD17B4
• Gene Alias: (3R)-hydroxyacyl-CoA dehydrogenase; 17[b]-HSD; 17beta-estradiol dehydrogenase type IV; 17-beta-HSD; 17-beta-HSD 4; 17-beta-HSD IV; 17-beta-hydroxysteroid dehydrogenase 4; 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholest-24-enoyl-CoA hydratase; 4; beta-hydroxyacyl dehydrogenase; beta-keto-reductase; D-3-hydroxyacyl-CoA dehydratase; D-bifunctional protein; D-bifunctional protein, peroxisomal; DBP; Edh17b4; Enoyl-CoA hydratase 2; Hsd17b4; hydroxysteroid (17-beta) dehydrogenase 4; hydroxysteroid 17-beta dehydrogenase 4; hydroxysteroid dehydrogenase 4; MFE-2; MFP2; Mfp-2; MPF-2; Multifunctional protein 2; perMFE-2; peroxisomal multifunctional enzyme type 2; peroxisomal multifunctional enzyme type II; peroxisomal multifunctional protein 2; PRLTS1; SDR8C1; Short chain dehydrogenase/reductase family 8C member 1; short chain dehydrogenase/reductase family 8C, member 1
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 3295, 79244
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Concentration: 1 mg/mL
• Formulation: 0.1M tris glycine with 10% glycerol and 0.01% thimerosal; pH 7
• Gene Accession No.: P51659, P97852
• Gene Symbols: HSD17B4
• Immunogen: Recombinant fragment corresponding to a region within amino acids 355 and 645 of HSD17B4 (Uniprot ID#P51659).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Rat
• Product Type: Antibody
• Isotype: IgG