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Invitrogen™ HSF2 Polyclonal Antibody
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Catalog No. PIPA588454
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100 μL
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PIPA588454 100 μL
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Catalog No. PIPA588454 Supplier Invitrogen™ Supplier No. PA588454
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: MLSGRQFSID PDLLVDLFTS SVQMNPTDYI NNTKSENKGL ETTKNNVVQP VSEEGRKSKS KPDKQLIQYT AFPLLAFLDG NPASSVEQAS TTASSEVLSS VDKPIEVDEL LDSSLDPEPT QSKLVRLEPL TEAEASEATL FYLCELAPAP LDSDMPLLDS; Positive Samples: U-87MG, LO2, HeLa, Mouse heart, Rat liver, Rat testis; Cellular Location: Cytoplasm, Nucleus.

Prokaryotic and eukaryotic cells respond to thermal and chemical stress by inducing a group of genes collectively designated heat shock genes. In eukaryotes, this gene expression is regulated primarily at the transcription level. Heat shock transcription factors (HSF, also designated HSTF) 1 and 2 are involved in this regulation. HSF1 and HSF2 are upregulated by estrogen at both the mRNA and protein level. HSF1 is normally found as a monomer whose transcriptional activity is repressed by constitutive phosphorylation. Upon activation, HSF1 forms trimers, gains DNA binding activity and is translocated to the nucleus. HSF2 activity is associated with differentiation and development, and, like HSF1, binds DNA as a trimer. Both HSF1 and HSF2 are known to be induced by proteasome inhibitors of the ubiquitin pathway.
TRUSTED_SUSTAINABILITY

Specifications

Antigen HSF2
Applications ELISA, Western Blot
Classification Polyclonal
Concentration 0.74 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.01% thimerosal; pH 7.3
Gene HSF2
Gene Accession No. P38533, Q03933
Gene Alias AI661205; heat shock factor 2; heat shock factor protein 2; Heat shock transcription factor 2; HSF 2; Hsf2; HSTF 2; HSTF2; MGC117376; MGC156196; MGC75048
Gene Symbols HSF2
Host Species Rabbit
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 377-536 of human HSF2 (NP_0044971).
Purification Method Affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 15500, 3298, 64441
Target Species Human, Mouse, Rat
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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