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Invitrogen™ HSP20 Polyclonal Antibody
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Catalog No. PIPA597286
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100 μL
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PIPA597286 100 μL
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Catalog No. PIPA597286 Supplier Invitrogen™ Supplier No. PA597286
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: MEIPVPVQPS WLRRASAPLP GLSAPGRLFD QRFGEGLLEA ELAALCPTTL APYYLRAPSV ALPVAQVPTD PGHFSVLLDV KHFSPEEIAV KVVGEHVEVH ARHEERPDEH GFVAREFHRR YRLPPGVDPA AVTSALSPEG VLSIQAAPAS AQAPPPAAAK; Positive Samples: Mouse lung; Cellular Location: Cytoplasm, Nucleus.

Heat Shock Protein 20 (HSP20), encoded by the HSPB6 gene, is a member of the small heat shock protein (sHSP) family, prominently involved in cellular stress response and maintenance of cytoskeletal integrity. HSP20 is ubiquitously expressed across various tissues, including cardiac and smooth muscle, where its roles are vital in modulating stress resilience and muscle function. It exerts protective effects against apoptosis and oxidative stress by interacting with cell signaling pathways that enhance cellular survival and protein stabilization. In cardiac muscle, HSP20 is known for its cardioprotective actions during ischemic injury, helping preserve myocardial function by inhibiting hypertrophic signaling pathways and promoting muscle relaxation. Studies highlight its involvement in vasodilation processes, as HSP20 interacts with myosin to regulate smooth muscle contraction and dilatation. Beyond its role in muscle physiology, HSP20 has been investigated for its potential therapeutic applications in cardiovascular diseases and metabolic disorders, where its expression and function could be pivotal in disease modulation and treatment strategies.
TRUSTED_SUSTAINABILITY

Specifications

Antigen HSP20
Applications ELISA, Western Blot
Classification Polyclonal
Concentration 0.92 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
Gene HSPB6
Gene Accession No. Q5EBG6
Gene Alias AA387366; cardiac heat shock protein p20; cardiac p20; epididymis luminal protein 55; Gm479; Heat shock 20 kDa-like protein p20; heat shock 20-kDa protein; Heat shock protein; heat shock protein 20kDa; heat shock protein beta-6; heat shock protein family B (small) member 6; heat shock protein family B (small) member B6; heat shock protein, alpha-crystallin-related, B6; HEL55; HSP; HSP20; HSPB6; p20; PPP1R91; protein phosphatase 1, regulatory subunit 91
Gene Symbols HSPB6
Host Species Rabbit
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 1-160 of human HSP20/HSP20/HSPB6 (NP_6532181).
Purification Method Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 243912
Target Species Mouse
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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