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Invitrogen™ HSP27 Monoclonal Antibody (8A7), FITC
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Catalog No. PIMA545122
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100 μg
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PIMA545122 100 μg
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Catalog No. PIMA545122 Supplier Invitrogen™ Supplier No. MA545122
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Description

Mouse Monoclonal Antibody

A 1:5000 dilution of MA5-45122 was sufficient for detection of HSP27 in 20 μg of HeLa cell lysate by ECL immunoblot analysis. Detects approximately 25kDa or approximately 27kDa. Recognizes HSP25 and HSP27, cross reacts with alpha B crystallin.

In response to adverse changes in their environment, cells from many organisms increase the expression of a class of proteins referred to as heat shock or stress proteins. HSPB1 (heat shock protein beta-1 or HSP27) is a small heat shock protein which functions as a molecular chaperone that maintains denatured proteins in a folding-competent state. It plays a role in stress resistance and actin organization. Through its molecular chaperone activity, HSP27 regulates numerous biological processes including the phosphorylation and the axonal transport of neurofilament proteins. Mutations in the gene can result in Charcot-Marie-Tooth disease 2F and Neuronopathy distal hereditary motor 2B.
TRUSTED_SUSTAINABILITY

Specifications

Antigen HSP27
Applications Flow Cytometry, Immunohistochemistry (Paraffin), Immunohistochemistry (PFA fixed), Immunoprecipitation, Western Blot, Immunocytochemistry
Classification Monoclonal
Clone 8A7
Concentration 1 mg/mL
Conjugate FITC
Formulation PBS, 9.1mM sodium bicarbonate with 640.91mM DMSO, 136.36mM ethanolamine and no preservative
Gene HSPB1
Gene Accession No. P04792, P14602, P42929, P42930, Q3T149
Gene Alias 27kDa; 28 kDa heat shock protein; CMT2F; DKFZp586P1322; epididymis secretory protein Li 102; estrogen-regulated 24 kDa protein; Growth-related 25 kDa protein; heat shock 25 kDa protein; Heat shock 27 kDa protein; heat shock 27kD protein 1; heat shock 27kDa protein 1; Heat shock protein; heat shock protein 1; heat shock protein 27 kDa beta-1; heat shock protein B1; heat shock protein beta-1; heat shock protein family B (small) member 1; heat shock protein, 25 kDa; heat-shock protein; HEL-S-102; HMN2B; HS; HS.76067; HSP; HSP 25; HSP 27; Hsp25; HSP27; HSP28; HSPB1; p25; Phospho-HSP 27; SRP27; Stress-responsive protein 27; truncated hsp25
Gene Symbols HSPB1
Host Species Mouse
Immunogen HSP27 peptide.
Purification Method Protein G
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 100724197, 100763481, 101115754, 15507, 24471, 3315, 403979, 516099
Target Species Human, Mouse, Rat, Canine, Bovine, Sheep, Hamster, Guinea Pig
Content And Storage 4°C, store in dark
Product Type Antibody
Form Liquid
Isotype IgG1 κ
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