HSP70 Mouse anti-Human, Mouse, Rat, Yeast, Clone: 4E7E5, Proteintech

Mouse Monoclonal Antibody

Supplier:  Proteintech Group Inc 661831IG150UL

Catalog No. 50-173-6617

Description

This antibody well recognized the endogenous HSP70 protein in multiple cell lines.

HSP70 is a Heat shock protein (HSP) which are expressed in response to various biological stresses, including high temperatures. There are several major families of HSPs that include HSP70, there are HSP90 and HSP100. The HSP70 family is a set of highly conserved proteins that are induced by a variety of biological stresses, including heat stress, in every organism in which the proteins have been examined. The human HSP70 family members include: HSP70, a protein which is strongly inducible in all organisms but which is also constitutively expressed in primate cells; HSP72, a 72 kDa protein that is induced exclusively under stress conditions; HSC70, or cognate protein, is a 72 kDa, constitutively expressed, protein which is involved in the uncoating of clathrin coated vesicles; GRP78, or BiP, is a glucose regulated 78 kDa protein localized in the endoplasmic reticulum; and p75, or HSP75, a 75 kDa protein that is found within the mitochondria. Further, HSP70 is encoded by an intronless gene and, in conjunction with other heat shock proteins, HSP70 stabilizes existing proteins against aggregation and mediates the folding of newly translated proteins in the cytosol and organelles. HSP70 is also involved in the ubiquitin-proteasome pathway through interaction with the AU-rich element RNA-binding protein 1. The HSP70 gene is located in the major histocompatibility complex class III region, in a cluster with two closely related genes which encode similar proteins.

Specifications

• Antigen: HSP70
• Classification: Monoclonal
• Concentration: 0.88 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene Accession No.: P0DMV8, P0DMW0, Q61696
• Gene Symbols: HSPA1A
• Immunogen: HSP70 Fusion Protein Ag19111
• Quantity: 150 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat, Yeast
• Product Type: Antibody
• Isotype: IgG1

• Applications: Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
• Clone: 4E7E5
• Conjugate: Unconjugated
• Gene: HSPA1A
• Gene Alias: Heat shock 70 kDa protein 1/2, heat shock 70kDa protein 1A, HSP70, HSP70 1, HSP70 1/HSP70 2, HSP70 1A, HSP70.1/HSP70.2, HSP70I, HSP72, HSPA1, HSPA1A, HSPA1B
• Host Species: Mouse
• Purification Method: Protein G
• Regulatory Status: RUO
• Gene ID (Entrez): 193740, 24472, 3303
• Content And Storage: -20°C
• Form: Liquid