Invitrogen™ HSP701L Polyclonal Antibody

Catalog No.	Quantity
PIPA528202	100 μL

Catalog No. PIPA528202 Supplier Invitrogen™ Supplier No. PA528202

Description

Rabbit Polyclonal Antibody

Recommended positive controls: 293T, A431, H1299, HeLaS3, HepG2, Molt-4, Raji, mouse testis, rat testis, U87-MG, SK-N-SH, IMR32, SK-N-AS. Predicted reactivity: Mouse (93%), Rat (92%), Xenopus laevis (81%), Pig (94%), Bovine (94%). Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

In response to adverse changes in their environment, cells from many organisms increase the expression of a class of proteins referred to as heat shock proteins. One class of stress proteins, termed the 'small heat shock proteins' is comprised of a diverse group of proteins from approximately15 to >30 kDa, with a single form found in yeast and human cells and multiple related forms found in higher plants. A direct relationship between elevated strwess protein expression and neoplasia has been suggested from studies on estrogen-induced proteins in breast cancer cells. In addition, Hsp27 exhibits rapid increased phosphorylation in response to various mitogens, tumor promoter (e. g. phorbol esters) and calcium ionophores. The expression of a 24 kDa protein was shown to correlate with steroid hormone receptor in cell lines, organs, and tumors. The 24 kDa estrogen-induced protein was found to be expressed at high levels in carcinoma of the breast. Another study has suggested that levels of the Hsp27 correlate with endometrial adenocarcinomas. Interestingly, the regulation of human Hsp27 by estrogens and heat shock is reminiscent of the ecdysteroid and heat shock activation of the drosophila Hsp20 genes.

Specifications

• Antigen: HSP701L
• Applications: Western Blot, Immunocytochemistry
• Classification: Polyclonal
• Concentration: 1 mg/mL
• Conjugate: Unconjugated
• Formulation: 0.1M tris glycine with 10% glycerol and 0.01% thimerosal; pH 7
• Gene: Hspa1l
• Gene Accession No.: P16627, P34931, P55063
• Gene Alias: heat shock 10kDa protein 1-like; heat shock 70 kDa protein 1-Hom; heat shock 70 kDa protein 1L; Heat shock 70 kDa protein 1-like; Heat shock 70 kDa protein 3; heat shock 70 kDa-like protein 1; heat shock 70kD protein-like 1; heat shock 70kDa protein 1-like; Heat shock protein; heat shock protein 1-like; Heat shock protein 70-1l; heat shock protein cognate 70, testis; heat shock protein family A (Hsp70) member 1 like; heat shock-related protein hsc70t; Hsc70t; HSP70.3; HSP70-1L; Hsp70-3; HSP70-HOM; HSP70T; Hspa1l; hum70t; inducible heat shock protein 70; Msh5; Spermatid-specific heat shock protein 70
• Gene Symbols: Hspa1l
• Host Species: Rabbit
• Immunogen: Recombinant protein encompassing a sequence within the center region of human HSP70 1L. The exact sequence is proprietary.
• Purification Method: Antigen affinity chromatography
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 15482, 24963, 3305
• Target Species: Human, Mouse, Rat
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov