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HSP90 alpha Mouse anti-Human, Clone: OTI3B5, Invitrogen™

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen MA525036

Catalog No. PIMA525036


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Description

Description

Heat shock proteins (HSP) are expressed in response to various biological stresses, including heat. HSP90 is a 90 kDa protein that is induced under stress conditions, but is also one of the most abundant cellular proteins found under non-stress conditions. HSP90 has been found to be associated with a number of other intracellular proteins, including steroid receptors, actin, tubulin, aryl hydrocarbon (Ah) receptor, and some kinases. Studies have shown that murine HSP90 exists as two forms, HSP84 and HSP86, coded by related but separate genes, with 86% amino acid sequence conservation. These forms are analogous to the two forms of human HSP90, HSP89 alpha and HSP89 beta. In an unstressed mouse fibroblast, the basal level of HSP84 is found to be double that of HSP86. However, after heat shock, HSP86 shows a greater increase. Studies also suggest that upon cellular differentiation, the level of HSP86, but not HSP84, decreases. HSP84 and HSP86, which may be subject to estrogenic regulation, have been found as components of the non-DNA binding form of mouse glucocorticoid receptor, but dissociated from the transformed DNA-binding form.
Specifications

Specifications

HSP90 alpha
Monoclonal
0.89 mg/mL
PBS with 1% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3
P07900
HSP86; HSP89A; HSP90A; HSP90N; HSPC1; HSPCA; HSPCAL1; HSPCAL4; HSPN; Hsp89; Hsp90; LAP2; HSP 86; heat shock 86 kDa; heat shock 90kD protein 1; alpha; heat shock 90kD protein 1; alpha-like 4; heat shock 90kD protein; alpha-like 4; heat shock 90kDa protein 1; alpha; heat shock protein HSP 90-alpha; renal carcinoma antigen NY-REN-38
Mouse
IgG1
100 μL
-20° C, Avoid Freeze/Thaw Cycles
Primary
3320
Western Blot
OTI3B5
Unconjugated
HSP90AA1
Liquid
HSP90AA1
Full length human recombit protein of HSP90AA1 produced in HEK293T cell
Affinity Chromatography
RUO
Antibody
Monoclonal
Human
Documents
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