Invitrogen™ HSP90 Monoclonal Antibody (AC-16), APC

Catalog No.	Quantity
PIMA545115	200 μg

Catalog No. PIMA545115 Supplier Invitrogen™ Supplier No. MA545115

Description

Mouse Monoclonal Antibody

1 μg/mL of MA5-45115 was sufficient for detection of HSP90 in 20 μg of heat shocked HeLa cell lysate by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody Detects 90kDa. This antibody is reactive with both the constitutive and the inducible form of HSP90. It does not bind to the native form and does not recognize HSP90 from E.coli or yeast.

HSP90 proteins are highly conserved molecular chaperones that have key roles in signal transduction, protein folding, protein degradation, and morphologic evolution. HSP90 proteins normally associate with other cochaperones and play important roles in folding newly synthesized proteins or stabilizing and refolding denatured proteins after stress. There are 2 major cytosolic HSP90 proteins, HSP90AA1, an inducible form, and HSP90AB1 and mitochondria (Chen et al., 2005 ).

Specifications

• Antigen: HSP90
• Applications: Immunohistochemistry (PFA fixed), Western Blot, Microarray
• Classification: Monoclonal
• Clone: AC-16
• Concentration: 1 mg/mL
• Conjugate: APC
• Formulation: 2.48mM MES, 95.64mM phosphate with 0.5M EDTA and no preservative; pH 7.4
• Gene: HSP90AB1
• Gene Accession No.: P07900, P07901, P08238, P11499, P11501, P30946, P30947, P34058, P82995, Q04619
• Gene Alias: 86kDa; 89kDa; 90kDa; 90-kDa heat shock protein; 90-kDa heat shock protein alpha; 90-kDa heat shock protein beta; AL022974; AL024080; AL024147; C81438; D6S182; EL52; epididymis luminal secretory protein 52; epididymis secretory sperm binding protein Li 65p; heat shock 84 kDa; Heat shock 86 kDa; heat shock 90 kDa protein; heat shock 90kD protein 1, alpha; heat shock 90kD protein 1, alpha-like 4; heat shock 90kD protein 1, beta; heat shock 90kD protein, alpha-like 4; heat shock 90kDa protein 1, alpha; heat shock 90kDa protein 1, beta; Heat shock protein; heat shock protein 1, alpha; heat shock protein 1, beta; heat shock protein 86; heat shock protein 90 alpha (cytosolic), class B member 1; heat shock protein 90 alpha family class A member 1; heat shock protein 90 alpha family class B member 1; heat shock protein 90 beta; heat shock protein 90 kDa; heat shock protein 90, alpha (cytosolic), class A member 1; heat shock protein 90kDa alpha (cytosolic), class A member 1; heat shock protein 90kDa alpha (cytosolic), class B member 1; heat shock protein 90kDa alpha family class A member 1; heat shock protein 90kDa alpha family class B member 1; heat shock protein HSP 90-alpha; Heat shock protein HSP 90-beta; heat shock protein, 1; heat shock protein, 84 kDa 1; heat shock protein, 86 kDa 1; heat shock protein, 89 kDa; HEL-S-65p; HSP; HSP 84; HSP 86; HSP 90; hsp4; HSP84; Hsp84-1; HSP86; Hsp86-1; Hsp89; HSP89A; Hsp90; HSP90A; Hsp90aa1; Hsp90ab1; HSP90B; HSP90-BETA; HSP90N; HSPC1; HSPC2; HSPCA; HSPCA protein; HSPCAL1; HSPCAL4; HSPCB; HSPN; LAP2; LAP-2; lipopolysaccharide-associated protein 2; LPS-associated protein 2; renal carcinoma antigen NY-REN-38; retinal degeneration slow protein; TSTA; Tumor-specific transplantation 84 kDa antigen; tumor-specific transplantation 86 kDa antigen; Unknown (protein for IMAGE:7943063)
• Gene Symbols: HSP90AA1, HSP90AB1
• Host Species: Mouse
• Immunogen: Heat shock protein 90 from the water mold Achyla ambisexualis.
• Purification Method: Protein G
• Quantity: 200 μg
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 100338694, 100358690, 15516, 15519, 299331, 301252, 3320, 3326, 396188, 423463
• Target Species: Human, Mouse, Rat, Rabbit, Chicken, Fungi, Plant, Insect
• Content And Storage: 4°C
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG2b